Patel Shruti R, Patel Kinjal D, Patel Jayendra B, Patel Prabhudas S, Shah Franky Dhaval
Biochemistry Research Division, Department of Cancer Biology, The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India.
Department of Cancer Biology, The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India.
J Cancer Res Ther. 2023 Jan 1;19(Suppl 2):S677-S681. doi: 10.4103/jcrt.jcrt_60_22. Epub 2023 Apr 30.
Recent literature suggests that vitamin D signaling has a protective effect against breast cancer risk. Thus, the aim of the present study was to find the association of vitamin D receptor (VDR) gene polymorphisms with breast cancer risk.
Fok1, Bsm1, Apa1, and Taq1 polymorphisms were performed by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) method, and Poly A polymorphism was carried out using PCR-SSCP in 140 breast cancer patients and 155 controls.
Odds ratio was significantly higher in both homozygous variant genotypes (LL) of Poly A polymorphism of VDR (odds ratio [OR] = 5.42, 95% confidence interval [CI] = 1.19-23.31, P = 0.02) and heterozygous variant genotypes (SL) of Poly A polymorphism of VDR (OR = 3.89, 95% CI = 1.10-13.7, P = 0.03). Fok1, Bsm1, Apa1, and Taq1 polymorphisms of VDR gene were not significantly associated with breast cancer risk.
Poly A polymorphism at the 3' untranslated region (UTR) of VDR gene was significantly associated with breast cancer risk in West Indian population.
近期文献表明维生素D信号传导对乳腺癌风险具有保护作用。因此，本研究的目的是探寻维生素D受体（VDR）基因多态性与乳腺癌风险之间的关联。
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法检测Fok1、Bsm1、Apa1和Taq1多态性，并运用PCR-SSCP检测140例乳腺癌患者和155例对照者的Poly A多态性。
VDR的Poly A多态性纯合变异基因型（LL）（优势比[OR]=5.42，95%置信区间[CI]=1.19-23.31，P=0.02）和杂合变异基因型（SL）（OR=3.89，95%CI=1.10-13.7，P=0.03）的优势比均显著更高。VDR基因的Fok1、Bsm1、Apa1和Taq1多态性与乳腺癌风险无显著关联。
在西印度人群中，VDR基因3'非翻译区（UTR）的Poly A多态性与乳腺癌风险显著相关。
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