Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Cukurova University, Adana, Turkey.
Faculty of Medicine, Department of Pediatrics, Division of Pediatric Cardiology, Cukurova University, Adana, Turkey.
J Clin Ultrasound. 2024 May;52(4):415-425. doi: 10.1002/jcu.23653. Epub 2024 Feb 22.
We aimed to investigate the role of lung ultrasound (LUS) score in the closure of hemodynamically insignificant patent ductus arteriosus (PDA) and the clinical findings of the patients before and after closure.
The study groups (107 preterm neonates under 34 gestational weeks) were classified as hemodynamically significant PDA (group 1), hemodynamically insignificant PDA with closure therapy (group 2), hemodynamically insignificant PDA without closure therapy (group 3), and no PDA group (group 4) based on the echocardiography. 6- and 10-region LUS scores were compared for each group.
There was a significant difference between groups 1 and 3 on first, third, and seventh days. In contrast, groups 1 and 2 had similar LUS scores on the first, third, and seventh days. There was a negative correlation between LUS scores on the first and third days and gestational age, birth weight, the first- and fifth-minute APGAR scores, and there was a positive correlation between aortic root to left atrium ratio, and PDA diameter/weight ratio.
We observed that LUS scores in patients with hemodynamically insignificant PDA treated with closure therapy were similar to in patients with hemodynamically significant PDA. Thus, LUS score can have role in PDA closure in preterm neonates. However, more comprehensive studies are needed.
我们旨在研究肺部超声(LUS)评分在治疗早产儿动脉导管未闭(PDA)中的作用,以及治疗前后患者的临床发现。
研究组(107 例胎龄小于 34 周的早产儿)根据超声心动图分为具有血流动力学意义的 PDA 组(1 组)、具有血流动力学意义的 PDA 并接受封堵治疗组(2 组)、具有血流动力学意义的 PDA 但未接受封堵治疗组(3 组)和无 PDA 组(4 组)。比较每组的 6 区和 10 区 LUS 评分。
第 1、3、7 天,1 组和 3 组之间存在显著差异。相比之下,1 组和 2 组第 1、3、7 天的 LUS 评分相似。第 1 天和第 3 天的 LUS 评分与胎龄、出生体重、第 1 分钟和第 5 分钟的 APGAR 评分呈负相关,与升主动脉至左心房的比值和 PDA 直径/体重比呈正相关。
我们观察到接受封堵治疗的具有血流动力学意义的 PDA 患者的 LUS 评分与具有血流动力学意义的 PDA 患者相似。因此,LUS 评分可以在早产儿 PDA 封堵中发挥作用。然而,还需要更全面的研究。