Lithell H, Vessby B, Selinus I, Dahlberg P A
Acta Endocrinol (Copenh). 1985 Jun;109(2):227-31. doi: 10.1530/acta.0.1090227.
Serum lipoprotein metabolism was studied in 7 women before and after treatment for thyrotoxicosis. Of the lipoprotein lipids, the triglyceride concentration in the low density lipoproteins (LDL) (P less than 0.01) and the cholesterol concentration in both LDL (P less than 0.01) and the high density lipoproteins (HDL) (P less than 0.05) increased significantly during treatment. These changes were accompanied by increases in apolipoprotein B (P less than 0.01) and A-I (P less than 0.05) concentrations in serum. Muscle lipoprotein lipase activity (LPLA) was increased in the thyrotoxic state by 46% (P less than 0.05) compared with the value after the patients had been rendered euthyroid, but adipose tissue LPLA was only 8% higher (ns) in the former state. The capacity for removal of exogenous fat, as determined by the fractional elimination rate (K2) at an iv fat tolerance test, was 23% higher in the thyrotoxic than in the euthyroid state (ns). It is suggested that the increase in muscle LPLA in the thyrotoxic state may be due to enhanced sensitivity to catecholamines. This may contribute to the increased capacity for plasma triglyceride turnover in thyrotoxicosis.
对7名甲状腺毒症女性患者治疗前后的血清脂蛋白代谢情况进行了研究。在脂蛋白脂质中，治疗期间低密度脂蛋白（LDL）中的甘油三酯浓度（P<0.01）以及LDL（P<0.01）和高密度脂蛋白（HDL）（P<0.05）中的胆固醇浓度均显著升高。这些变化伴随着血清中载脂蛋白B（P<0.01）和A-I（P<0.05）浓度的升高。与患者甲状腺功能恢复正常后的数值相比，甲状腺毒症状态下肌肉脂蛋白脂肪酶活性（LPLA）升高了46%（P<0.05），但在前一种状态下脂肪组织LPLA仅高8%（无统计学意义）。通过静脉脂肪耐量试验中的分数消除率（K2）测定，甲状腺毒症状态下清除外源性脂肪的能力比甲状腺功能正常状态高23%（无统计学意义）。提示甲状腺毒症状态下肌肉LPLA的升高可能是由于对儿茶酚胺的敏感性增强。这可能有助于甲状腺毒症患者血浆甘油三酯周转率的提高。
