Department of Public Health Sciences, The University of Chicago, Chicago, IL 60637, USA.
Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Int J Environ Res Public Health. 2024 Feb 14;21(2):222. doi: 10.3390/ijerph21020222.
(1) Objectives: To investigate the effect of individual-level, neighborhood, and environmental variables on uterine fibroid (UF) prevalence in a Chicago-based cohort. (2) Methods: Data from the Chicago Multiethnic Prevention and Surveillance Study (COMPASS) were analyzed. Individual-level variables were obtained from questionnaires, neighborhood variables from the Chicago Health Atlas, and environmental variables from NASA satellite ambient air exposure levels. The Shapiro-Wilk test, logistic regression models, and Spearman's correlations were used to evaluate the association of variables to UF diagnosis. (3) Results: We analyzed 602 participants (mean age: 50.3 ± 12.3) who responded to a question about UF diagnosis. More Black than White participants had a UF diagnosis (OR, 1.32; 95% CI, 0.62-2.79). We observed non-significant trends between individual-level and neighborhood variables and UF diagnosis. Ambient air pollutants, PM2.5, and DSLPM were protective against UF diagnosis (OR 0.20, CI: 0.04-0.97: OR 0.33, CI: 0.13-0.87). (4) Conclusions: Associations observed within a sample in a specific geographic area may not be generalizable and must be interpreted cautiously.
(1) 目的：在芝加哥的队列研究中，调查个体、社区和环境变量对子宫肌瘤（UF）患病率的影响。
(2) 方法：分析了芝加哥多种族预防和监测研究（COMPASS）的数据。个体水平变量来自问卷，社区水平变量来自芝加哥健康地图集，环境变量来自 NASA 卫星环境空气暴露水平。使用 Shapiro-Wilk 检验、逻辑回归模型和 Spearman 相关系数来评估变量与 UF 诊断的关联。
(3) 结果：我们分析了 602 名参与者（平均年龄：50.3 ± 12.3），他们回答了一个关于 UF 诊断的问题。与白人相比，黑人参与者的 UF 诊断率更高（OR，1.32；95%CI，0.62-2.79）。我们观察到个体水平和社区变量与 UF 诊断之间存在非显著趋势。空气污染物 PM2.5 和 DSLPM 对 UF 诊断具有保护作用（OR 0.20，CI：0.04-0.97；OR 0.33，CI：0.13-0.87）。
(4) 结论：在特定地理区域的样本中观察到的关联可能不具有普遍性，必须谨慎解释。
Zotero 插件