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A Scoping Review on the Use of Non-Invasive Brain Stimulation Techniques for Persistent Post-Concussive Symptoms.

作者信息

Khosravi Mohammad Hossein, Louras Mélanie, Martens Géraldine, Kaux Jean-François, Thibaut Aurore, Lejeune Nicolas

机构信息

Coma Science Group, GIGA Consciousness, University of Liège, 4000 Liège, Belgium.

Centre du Cerveau², University Hospital of Liège, 4000 Liège, Belgium.

出版信息

Biomedicines. 2024 Feb 17;12(2):450. doi: 10.3390/biomedicines12020450.


DOI:10.3390/biomedicines12020450
PMID:38398052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10887310/
Abstract

BACKGROUND: In the context of managing persistent post-concussive symptoms (PPCS), existing treatments like pharmacotherapy, cognitive behavioral therapy, and physical rehabilitation show only moderate effectiveness. The emergence of neuromodulation techniques in PPCS management has led to debates regarding optimal stimulation parameters and their overall efficacy. METHODS: this scoping review involved a comprehensive search of PubMed and ScienceDirect databases, focusing on controlled studies examining the therapeutic potential of non-invasive brain stimulation (NIBS) techniques in adults with PPCS. RESULTS: Among the 940 abstracts screened, only five studies, encompassing 103 patients (12 to 29 per study), met the inclusion criteria. These studies assessed the efficacy of transcranial direct current stimulation (tDCS), or repetitive transcranial magnetic stimulation (rTMS), applied to specific brain regions (i.e., the left dorsolateral pre-frontal cortex (DLPFC) or left motor cortex (M1)) for addressing cognitive and psychological symptoms, headaches, and general PPCSs. The results indicated improvements in cognitive functions with tDCS. In contrast, reductions in headache intensity and depression scores were observed with rTMS, while no significant findings were noted for general symptoms with rTMS. CONCLUSION: although these pilot studies suggest promise for rTMS and tDCS in PPCS management, further research with larger-scale investigations and standardized protocols is imperative to enhance treatment outcomes for PPCS patients.

摘要

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A Scoping Review on the Use of Non-Invasive Brain Stimulation Techniques for Persistent Post-Concussive Symptoms.

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本文引用的文献

[1]
Consensus statement on concussion in sport: the 6th International Conference on Concussion in Sport-Amsterdam, October 2022.

Br J Sports Med. 2023-6

[2]
Targeted interventions and their effect on recovery in children, adolescents and adults who have sustained a sport-related concussion: a systematic review.

Br J Sports Med. 2023-6

[3]
Rest and exercise early after sport-related concussion: a systematic review and meta-analysis.

Br J Sports Med. 2023-6

[4]
Clinical recovery from concussion-return to school and sport: a systematic review and meta-analysis.

Br J Sports Med. 2023-6

[5]
Orbitofrontal cortex-hippocampus potentiation mediates relief for depression: A randomized double-blind trial and TMS-EEG study.

Cell Rep Med. 2023-6-20

[6]
The American Congress of Rehabilitation Medicine Diagnostic Criteria for Mild Traumatic Brain Injury.

Arch Phys Med Rehabil. 2023-8

[7]
Gender Specificities in Sleep Disturbances following Mild Traumatic Brain Injury: A Preliminary Study.

Brain Sci. 2023-2-14

[8]
Acute thalamic connectivity precedes chronic post-concussive symptoms in mild traumatic brain injury.

Brain. 2023-8-1

[9]
Management of Psychological Complications Following Mild Traumatic Brain Injury.

Curr Neurol Neurosci Rep. 2023-3

[10]
Randomized controlled trial of early aerobic exercise following sport-related concussion: Progressive percentage of age-predicted maximal heart rate versus usual care.

PLoS One. 2022

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