胃肠癌和结直肠癌手术中的精准肿瘤学。

Precision Oncology in Gastrointestinal and Colorectal Cancer Surgery.

机构信息

Department of General Surgery, Division of Surgical Oncology, The University of Kentucky, 800 Rose Street, Lexington, KY 40508, USA.

Department of General Surgery, Division of Surgical Oncology, Yale University, 15 York Street, New Haven, CT 06510, USA.

出版信息

Surg Oncol Clin N Am. 2024 Apr;33(2):321-341. doi: 10.1016/j.soc.2023.12.007. Epub 2024 Jan 9.

DOI:10.1016/j.soc.2023.12.007

PMID:38401913

Abstract

Precision medicine is used to treat gastrointestinal malignancies including esophageal, gastric, small bowel, colorectal, and pancreatic cancers. Cutting-edge assays to detect and treat these cancers are active areas of research and will soon become standard of care. Colorectal cancer is a prime example of precision oncology as disease site is no longer the final determinate of treatment. Here, the authors describe how leveraging an understanding of tumor biology translates to individualized patient care using evidence-based practices.

摘要

精准医学用于治疗胃肠道恶性肿瘤，包括食管癌、胃癌、小肠癌、结直肠癌和胰腺癌。用于检测和治疗这些癌症的尖端检测方法是研究的活跃领域，并将很快成为标准治疗方法。结直肠癌是精准肿瘤学的一个主要范例，因为疾病部位不再是治疗的最终决定因素。在这里，作者描述了如何利用对肿瘤生物学的理解转化为基于证据的实践的个体化患者护理。