Colten Sridevi S, di Cantogno Elisabetta Verdun, Jack Dominic
Department of MS Market Research & Analysis, EMD Serono Research and Development Institute, Inc. (an Affiliate of Merck KGaA), Billerica, MA, USA.
Department of MS Medical Affairs, EMD Serono Research and Development Institute, Inc. (an Affiliate of Merck KGaA), Billerica, MA, USA.
Med Devices (Auckl). 2024 Feb 19;17:59-71. doi: 10.2147/MDER.S438883. eCollection 2024.
RebiSmart is an electromechanical multidose autoinjector developed for administering subcutaneous interferon beta-1a in patients with multiple sclerosis (pwMS). This online survey aimed to understand MS nurses' and pwMS preferences and perceptions regarding the features of an upgraded version of the RebiSmart device (RebiSmart 3.0) compared to other assistive devices used for multiple sclerosis (MS) therapy.
Eligible MS nurses and pwMS from Germany, Italy, and the United Kingdom completed a double-blind, 30-minute online self-administered questionnaire, including a 10-minute video describing the features of RebiSmart 3.0 and its use in administering interferon beta-1a.
In total, 102 participants (MS nurses, n=52; patients, n=50) completed the survey. Overall, 70% respondents found the RebiSmart 3.0 device "very"/"extremely" appealing, 53% were "very"/"extremely" interested in learning more, and 71% stated they would be "very"/"extremely" comfortable using (pwMS) or educating (MS nurses) on it. Among current or recent RebiSmart 2.0 users (vs RebiSmart 2.0 nonusers), 67% (vs 52%) rated RebiSmart 3.0 "very" or "extremely" appealing, 52% (vs 43%) were "very" or "extremely" interested in learning more about the device, and 67% (vs 48%) stated they would be "very" or "extremely" comfortable using the RebiSmart 3.0 device. Respondents ranked customizable injection process (including injection speed, hold time, depth and rotation guide), self-injection process, and hidden needle as the most important self-assistive device features. RebiSmart 3.0 was rated higher than other self-injecting devices on all tested features. Overall, with respect to the top three features, 89% of the MS nurses and 73% of PwMS rated RebiSmart 3.0 "very good" or "excellent". After reviewing the video, 52% respondents had no questions, 67% nurses recommended providing more information on the customizable injection process feature of RebiSmart 3.0 to patients, and 88% nurses considered patient demonstration materials to be the most helpful type of information for them when initiating and educating pwMS on self-assistive devices.
The overall reactions of MS nurses and pwMS to the RebiSmart 3.0 device features were positive. The incremental advances over previous versions of the device as well as in comparison with other currently available assistive devices were welcomed. The MS nurses identified key needs for patient education on the use of the device and the suitable approaches (training videos and educational leaflets) to support MS nurses and pwMS.
RebiSmart是一款机电式多剂量自动注射器，专为给多发性硬化症患者（pwMS）皮下注射干扰素β-1a而研发。这项在线调查旨在了解MS护士和pwMS患者对于RebiSmart设备升级版（RebiSmart 3.0）相较于用于多发性硬化症（MS）治疗的其他辅助设备的功能特点的偏好和看法。
来自德国、意大利和英国的符合条件的MS护士和pwMS患者完成了一份30分钟的双盲在线自填问卷，其中包括一段10分钟的视频，介绍RebiSmart 3.0的功能及其在注射干扰素β-1a中的使用方法。
共有102名参与者（MS护士，n = 52；患者，n = 50）完成了调查。总体而言，70%的受访者认为RebiSmart 3.0设备“非常”/“极其”有吸引力，53%的人“非常”/“极其”有兴趣了解更多，71%的人表示他们在使用（pwMS患者）或讲解（MS护士）该设备时会“非常”/“极其”舒适。在当前或近期使用过RebiSmart 2.0的用户（与未使用过RebiSmart 2.0的用户相比）中，67%（对比52%）将RebiSmart 3.0评为“非常”或“极其”有吸引力，52%（对比43%）的人“非常”或“极其”有兴趣进一步了解该设备，67%（对比48%）的人表示他们使用RebiSmart 3.0设备会“非常”或“极其”舒适。受访者将可定制的注射过程（包括注射速度、保持时间、深度和旋转指导）、自我注射过程以及隐藏针头列为最重要的自我辅助设备功能。在所有测试功能方面，RebiSmart 3.0的评分均高于其他自我注射设备。总体而言，就前三项功能而言，89%的MS护士和73%的pwMS患者将RebiSmart 3.0评为“非常好”或“优秀”。观看视频后，52%的受访者没有问题，67%的护士建议向患者提供更多关于RebiSmart 3.0可定制注射过程功能的信息，88%的护士认为患者演示材料是在向pwMS患者介绍和讲解自我辅助设备时对他们最有帮助的信息类型。
MS护士和pwMS患者对RebiSmart 3.0设备功能的总体反应是积极的。该设备相较于先前版本以及与其他现有辅助设备相比的渐进式改进受到欢迎。MS护士确定了患者在使用该设备方面的关键教育需求以及支持MS护士和pwMS患者的合适方法（培训视频和教育传单）。
