Department of Emergency Medicine, University of Health Sciences, Haseki Training and Research Hospital, Istanbul, Turkey.
Department of Emergency Medicine, Istanbul Beylikdüzü State Hospital, Istanbul, Turkey.
Niger J Clin Pract. 2024 Feb 1;27(2):244-251. doi: 10.4103/njcp.njcp_507_23. Epub 2024 Feb 26.
We investigated predictors of mortality, including demographic, clinical, and laboratory parameters, in hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia.
This retrospective, single-center study included 651 consecutive Turkish adults who had been admitted to the emergency department with a diagnosis of COVID-19. We recorded the demographic, clinical, and laboratory parameters of the patients. The patients were divided into two groups: patients aged ≥65 years and patients aged <65 years. The predictors of mortality for hospitalized COVID-19 patients were evaluated.
The study included 651 patients (354 [54.4%] men and 297 [45.6%] women; mean age, 56.40 ± 15.70 years). The most common comorbidities were hypertension (37.6%), diabetes mellitus (28.9%), and coronary artery disease (CAD) (16.1%). The overall mortality rate was 10.6% (n = 69); the mortality rate was higher in men than in women. Advanced age; chronic renal failure (CRF); prolonged activated partial thromboplastin time; high serum neutrophil and platelet counts; high C-reactive protein to albumin (CRP/albumin) ratio; and high levels of albumin, lactate dehydrogenase (LDH), and high-sensitivity troponin I (TnI-hs) were independent predictors of mortality in all age groups.
Multivariate logistic regression analysis showed that chronic obstructive pulmonary disease (COPD), high serum platelet count, high CRP/albumin ratio, and high levels of albumin, TnI-hs, and D-dimer were independent predictors of mortality in patients aged <65 years. Conversely, advanced age, CAD, CRF, and high levels of serum CRP and LDH were independent predictors of mortality in patients aged ≥65 years.
我们研究了包括人口统计学、临床和实验室参数在内的预测因素，以了解住院的 2019 冠状病毒病（COVID-19）肺炎患者的死亡率。
这是一项回顾性、单中心研究，纳入了 651 名连续就诊于急诊科并被诊断为 COVID-19 的土耳其成年人。我们记录了患者的人口统计学、临床和实验室参数。将患者分为两组：年龄≥65 岁的患者和年龄<65 岁的患者。评估了住院 COVID-19 患者的死亡率预测因素。
本研究纳入了 651 名患者（354 名男性[54.4%]和 297 名女性[45.6%]；平均年龄 56.40±15.70 岁）。最常见的合并症是高血压（37.6%）、糖尿病（28.9%）和冠状动脉疾病（CAD）（16.1%）。总的死亡率为 10.6%（n=69）；男性的死亡率高于女性。高龄；慢性肾衰竭（CRF）；延长的活化部分凝血活酶时间；高血清中性粒细胞和血小板计数；高 C 反应蛋白与白蛋白比值（CRP/albumin）；以及高白蛋白、乳酸脱氢酶（LDH）和高敏肌钙蛋白 I（TnI-hs）水平是所有年龄段患者死亡的独立预测因素。
多变量逻辑回归分析显示，慢性阻塞性肺疾病（COPD）、高血清血小板计数、高 CRP/albumin 比值以及高白蛋白、TnI-hs 和 D-二聚体水平是年龄<65 岁患者死亡的独立预测因素。相反，高龄、CAD、CRF 以及高血清 CRP 和 LDH 水平是年龄≥65 岁患者死亡的独立预测因素。
