Pharmacology Department, Faculty of Pharmacy, Başkent University.
Clinical Pharmacy and Drug Information Center, Ankara Hospital, Başkent University.
J Chemother. 2024 Oct;36(6):474-482. doi: 10.1080/1120009X.2024.2321015. Epub 2024 Feb 26.
Meticulous antimicrobial management is essential among critically ill patients with acute kidney injury, particularly if renal replacement therapy is needed. Many factors affect drug removal in patients undergoing continuous renal replacement therapy CRRT. In this study, we aimed to compare current databases that are frequently used to adjust CRRT dosages of antimicrobial drugs with the gold standard. The dosage recommendations from various databases for antimicrobial drugs eliminated by CRRT were investigated. The book 'Renal Pharmacotherapy: Dosage Adjustment of Medications Eliminated by the Kidneys' was chosen as the gold standard. There were variations in the databases. Micromedex, UpToDate, and Sanford had similar rates to the gold standard of 45%, 35%, and 30%, respectively. The Micromedex database shows the most similar results to the gold standard source. In addition, a consensus was reached as a result of the expert panel meetings established to discuss the different antimicrobial dose recommendations of the databases.
在需要肾脏替代治疗的急性肾损伤危重症患者中，需要进行细致的抗菌药物管理。许多因素会影响连续肾脏替代治疗（CRRT）患者的药物清除率。在这项研究中，我们旨在比较目前常用的调整 CRRT 剂量的抗菌药物数据库与金标准。研究了各种数据库对抗生素药物剂量的推荐，这些药物是通过 CRRT 消除的。《肾脏药物治疗学：经肾脏消除药物的剂量调整》一书被选为金标准。各数据库之间存在差异。Micromedex、UpToDate 和 Sanford 的结果与金标准的比例分别为 45%、35%和 30%相似。Micromedex 数据库显示与金标准来源最相似的结果。此外，通过专家小组会议达成了共识，以讨论数据库中不同的抗菌药物剂量推荐。
