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3 岁儿童脊髓星形母细胞瘤,MN1 改变:不常见部位的罕见肿瘤。

Spinal astroblastoma, MN1 altered in 3-year-old child: An uncommon tumor at an unusual site.

机构信息

Department of Pathology, Agilus Diagnostics Ltd-Fortis Memorial Research Institute (FMRI), Gurugram, India.

Neuropathology Laboratory, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Neuropathology. 2024 Aug;44(4):314-318. doi: 10.1111/neup.12965. Epub 2024 Feb 26.

Abstract

Astroblastoma is an uncommon circumscribed glial tumor mostly involving the cerebral hemisphere. The characteristic molecular alteration is meningioma (disrupted in balanced translocation) 1 (MN1) rearrangement. No definite World Health Organization grade has been assigned as both low- and high-grade tumors are known to occur. Tumors in the spine are extremely rare; to date only three cases have been reported in the literature. A vigilant microscopy and ancillary testing aid in diagnosis when the tumors present in unusual locations, as in our case. The prompt differentiation of this tumor from its mimickers is a mandate as modalities of management are different and not clearly established.

摘要

星形母细胞瘤是一种少见的局限性神经胶质肿瘤,主要发生于大脑半球。其特征性的分子改变是脑膜瘤(易位断裂)1 号基因(meningioma 1,MN1)重排。目前尚无明确的世界卫生组织分级,因为已知既有低级别肿瘤也有高级别肿瘤。脊柱肿瘤极其罕见;迄今为止,文献中仅报道了 3 例。当肿瘤出现在不常见的部位时,如本例,仔细的显微镜检查和辅助检查有助于诊断。迅速将该肿瘤与其类似物区分开来是必要的,因为其治疗方式不同,且尚未明确。

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