Lasocki Sigismond, Belbachir Anissa, Mertes Paul-Michel, Le Pelley Eric, Bosch Laetitia, Bezault Clémence, Belarbia Samia, Capdevila Xavier
From the Département Anesthésie Réanimation, CHU Angers, Angers, France.
Department of Anesthesia and Critical Care Medicine, Cochin University Paris-Descartes Hospital, Paris, France.
Anesth Analg. 2025 Feb 1;140(2):453-464. doi: 10.1213/ANE.0000000000006917. Epub 2024 Feb 27.
Patient blood management (PBM) is an evidence-based approach recommended to improve patient outcomes. Change in practices is often challenging. We report here data from French surgical departments before and after a standardized implementation of a PBM program.
This was a national, multicenter, observational study in surgical centers ("expert" centers with an already established protocol for preoperative anemia or "pilot" centers). Data from consecutive surgical patients of different specialties were retrieved before and after the implementation of a PBM program. Primary outcome variables (preoperative anemia treatment rates, transfusion rates, and length of hospital stay) before and after the implementation of a PBM program were analyzed with segmented regression adjusted on confounders (American Society of Anesthesiologists [ASA] scores and centers).
A total of 1618 patients (ASA physical status III and IV, 38% in the first period and 45% in the second period) were included in expert (N = 454) or pilot (N = 1164) centers during the first period (January 2017-August 2022) and 1542 (N = 440 and N = 1102, respectively) during the second period (January 2020-February 2023). After implementation of the PBM program, the rate of preoperative anemia treatment increased (odds ratio, 2.37; 95% confidence interval [CI], 1.20-4.74; P = .0136) and length of hospital stay in days decreased (estimate, -0.11; 95% CI, -0.21 to -0.02; P = .0186). Transfusion rate significantly decreased only in expert centers (odds ratio, 0.17; 95% CI, 0.03-0.88; P = .0354).
PBM practices in various surgical specialties improved significantly after the implementation of a PBM program. However, too many patients with preoperative anemia remained untreated.
患者血液管理(PBM)是一种基于证据的方法,推荐用于改善患者预后。实践中的改变往往具有挑战性。我们在此报告法国外科科室在标准化实施PBM项目前后的数据。
这是一项在外科中心(有术前贫血既定方案的“专家”中心或“试点”中心)开展的全国性、多中心观察性研究。在实施PBM项目前后,收集不同专科连续手术患者的数据。使用对混杂因素(美国麻醉医师协会[ASA]评分和中心)进行调整的分段回归分析PBM项目实施前后的主要结局变量(术前贫血治疗率、输血率和住院时间)。
在第一阶段(2017年1月至2022年8月),共有1618例患者(ASA身体状况III级和IV级,第一阶段为38%,第二阶段为45%)纳入专家中心(N = 454)或试点中心(N = 1164),第二阶段(2020年1月至2023年2月)为1542例(分别为N = 440和N = 1102)。实施PBM项目后,术前贫血治疗率有所提高(优势比,2.37;95%置信区间[CI],1.20 - 4.74;P = 0.0136),住院天数减少(估计值,-0.11;95%CI,-0.21至-0.02;P = 0.0186)。仅在专家中心输血率显著降低(优势比,0.17;95%CI,0.03 - 0.88;P = 0.0354)。
实施PBM项目后,各外科专科的PBM实践有显著改善。然而,仍有太多术前贫血患者未得到治疗。