Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Eur J Gastroenterol Hepatol. 2024 Apr 1;36(4):394-403. doi: 10.1097/MEG.0000000000002734. Epub 2024 Feb 28.
OBJECTIVE: We measured the fecal levels of short-chain fatty acids (SCFAs) in subjects with slow transit constipation (STC) and assessed the correlation between SCFA levels and disease severity as well as quality of life. METHODS: We isolated the supernatant from fecal samples of healthy and STC subjects and measured the SCFA levels. To assess the correlation between fecal SCFA levels and disease severity as well as quality of life, we used the Constipation Scoring System, Patient Assessment of Constipation Symptoms, and Patient Assessment of Constipation Quality of Life questionnaires. RESULTS: 16 STC subjects and 16 healthy controls were enrolled. STC subjects had lower SCFA levels, but the difference was not statistically significant (475.85 ± 251.68 vs. 639.77 ± 213.97 µg/ml, P = 0.056). Additionally, STC subjects had lower acetic and propionic acid levels (149.06 ± 88.54 vs. 261.33 ± 109.75 µg/ml and 100.60 ± 60.62 vs. 157.34 ± 66.37 µg/ml, respectively, P < 0.05) and higher isobutyric and isovaleric acid levels (27.21 ± 15.06 vs. 18.16 ± 8.65 µg/ml and 31.78 ± 18.81 vs. 16.90 ± 10.05 µg/ml, respectively, P < 0.05). At 252.21 µg/ml acetic acid, the specificity and sensitivity to distinguish healthy from STC subjects were 93.7% and 56.3%, respectively. In STC subjects, there were significant negative correlations between acetic and propionic acid levels and Constipation Scoring System scores. CONCLUSION: Fecal SCFA, acetic acid, and propionic acid levels decreased in STC subjects. There were significant negative correlations between the levels of the two acids and constipation severity.
目的：我们测量了慢传输型便秘（STC）患者粪便中短链脂肪酸（SCFA）的水平，并评估了 SCFA 水平与疾病严重程度和生活质量之间的相关性。
方法：我们从健康人和 STC 患者的粪便样本中分离出上清液，并测量了 SCFA 水平。为了评估粪便 SCFA 水平与疾病严重程度和生活质量之间的相关性，我们使用了便秘评分系统、患者便秘症状评估和患者便秘生活质量评估问卷。
结果：共纳入 16 名 STC 患者和 16 名健康对照者。STC 患者的 SCFA 水平较低，但差异无统计学意义（475.85±251.68 vs. 639.77±213.97µg/ml，P=0.056）。此外，STC 患者的乙酸和丙酸水平较低（149.06±88.54 vs. 261.33±109.75µg/ml 和 100.60±60.62 vs. 157.34±66.37µg/ml，均 P<0.05），异丁酸和异戊酸水平较高（27.21±15.06 vs. 18.16±8.65µg/ml 和 31.78±18.81 vs. 16.90±10.05µg/ml，均 P<0.05）。在 252.21µg/ml 乙酸时，区分健康人和 STC 患者的特异性和敏感性分别为 93.7%和 56.3%。在 STC 患者中，乙酸和丙酸水平与便秘评分系统评分呈显著负相关。
结论：STC 患者粪便 SCFA、乙酸和丙酸水平降低。这两种酸的水平与便秘严重程度呈显著负相关。
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