Health Management Center, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Translational Informatics Center, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610212, China.
Sci Rep. 2024 Feb 28;14(1):4848. doi: 10.1038/s41598-024-55475-x.
To compare the LDCT screening results between eligible and ineligible screening candidates in preventive health check-ups population. Using a real-world LDCT screening results among people who took yearly health check-up in health management center of West China Hospital between 2006 and 2017. Objects were classified according to the China National Lung Cancer Screening Guideline with Low-dose Computed Tomography (2018 version) eligibility criteria. Descriptive analysis were performed between eligible and ineligible screening candidates. The proportion of ineligible screening candidates was 64.13% (10,259), and among them there were 4005 (39.04%) subjects with positive screenings, 80 cases had a surgical lung biopsy. Pathology results from lung biopsy revealed 154 cancers (true-positive) and 26 benign results (false-positive), the surgical false-positive biopsy rate was 4.17%, and ineligible group (7.69%) was higher than eligible group (2.47%), P < 0.05. Further, in ineligible screening candidates, the proportion of current smokers was higher among males compared to females (53.85% vs. 4.88%, P < 0.05). Of the 69 lung cancer patients detected in ineligible screening candidates, lung adenocarcinoma accounts for a high proportion of lung cancers both in male (75.00%) and female (85.00%). The proportion of ineligible screening candidates and the surgical false-positive biopsy rate in ineligible candidates were both high in health check-ups population.
比较在预防性健康检查人群中合格和不合格筛查候选者的 LDCT 筛查结果。使用华西医院健康管理中心 2006 年至 2017 年期间进行的年度健康检查人群的真实 LDCT 筛查结果。根据中国国家肺癌筛查指南（2018 年版）的低剂量计算机断层扫描（LDCT）资格标准对对象进行分类。对合格和不合格筛查候选者进行描述性分析。不合格筛查候选者的比例为 64.13%（10,259），其中有 4005（39.04%）例阳性筛查，80 例进行了手术性肺活检。肺活检的病理结果显示 154 例癌症（真阳性）和 26 例良性结果（假阳性），手术性假阳性活检率为 4.17%，不合格组（7.69%）高于合格组（2.47%），P < 0.05。此外，在不合格筛查候选者中，男性中当前吸烟者的比例高于女性（53.85%比 4.88%，P < 0.05）。在不合格筛查候选者中发现的 69 例肺癌患者中，肺腺癌在男性（75.00%）和女性（85.00%）中均占肺癌的很大比例。不合格筛查候选者的比例和不合格组中的手术性假阳性活检率在健康检查人群中均较高。
