新冠后中枢性睡眠过多，一种长新冠中的可治疗特征：4例病例报告
Post-COVID central hypersomnia, a treatable trait in long COVID: 4 case reports.
作者信息
Morelli-Zaher Clémence, Vremaroiu-Coman Andrea, Coquoz Nicolas, Genecand Léon, Altarelli Marco, Binkova Alzbeta, Frésard Isabelle, Bridevaux Pierre-Olivier, Gex Grégoire
机构信息
Division of Pulmonology, Centre Hospitalier du Valais Romand, Hôpital du Valais, Sion, Switzerland.
Division of Pulmonology, Geneva University Hospitals, Geneva, Switzerland.
出版信息
Front Neurol. 2024 Feb 14;15:1349486. doi: 10.3389/fneur.2024.1349486. eCollection 2024.
INTRODUCTION
Fatigue is the most commonly reported post-COVID symptom. A minority of patients also report excessive daytime sleepiness, which could be a target for treatment.
METHODS
Among 530 patients with a post-COVID condition, those with excessive daytime sleepiness were systematically assessed for objective central hypersomnia, with exclusion of all cases not clearly attributable to SARS-CoV-2 infection.
RESULTS
Four cases of post-COVID central hypersomnia were identified, three fulfilling the criteria of the 3rd International Classification of Sleep Disorders for idiopathic hypersomnia, and one for type II narcolepsy. We report here their clinical history, sleep examination data and treatment, with a favorable response to methylphenidate in three cases and spontaneous resolution in one case.
CONCLUSION
We highlight the importance of identifying cases of post-COVID central hypersomnia, as it may be a treatable trait of a post-COVID condition.
引言
疲劳是新冠感染后最常报告的症状。少数患者还报告有日间过度嗜睡，这可能是治疗的一个靶点。
方法
在530例新冠感染后患者中，对有日间过度嗜睡的患者进行了客观中枢性过度嗜睡的系统评估，排除了所有不能明确归因于SARS-CoV-2感染的病例。
结果
确定了4例新冠感染后中枢性过度嗜睡病例，其中3例符合《国际睡眠障碍分类第3版》特发性过度嗜睡的标准，1例符合发作性睡病II型的标准。我们在此报告他们的临床病史、睡眠检查数据和治疗情况，3例对哌甲酯治疗反应良好，1例自行缓解。
结论
我们强调识别新冠感染后中枢性过度嗜睡病例的重要性，因为它可能是新冠感染后状况的一个可治疗特征。
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