Delaleu Jérémie, Bouaziz Jean-David
Dermatology Department, Saint Louis Hospital, APHP Nord Université Paris Cité and INSERM u976 "Human Immunology, Pathophysiology and Immunotherapy", Paris, France.
Dermatology Department, Saint Louis Hospital, APHP Nord Université Paris Cité and INSERM u976 "Human Immunology, Pathophysiology and Immunotherapy", Paris, France.
Dermatol Clin. 2024 Apr;42(2):147-156. doi: 10.1016/j.det.2023.08.002. Epub 2023 Sep 14.
Neutrophilic dermatoses are a group of inflammatory skin conditions characterized by a neutrophilic infiltrate on histopathology with no evidence of infection. These conditions present with a wide range of clinical manifestations, including pustules, bullae, abscesses, papules, nodules, plaques, and ulcers. The classification of neutrophilic dermatoses is based on the localization of neutrophils in the skin. The pathogenic mechanisms of neutrophilic dermatoses involve autoinflammation, neutrophilic dysfunction, clonal somatic mutation and differentiation of the myeloid precursors as encountered in myeloid neoplasm.
嗜中性皮病是一组炎症性皮肤病，其组织病理学特征为嗜中性粒细胞浸润，且无感染证据。这些病症具有广泛的临床表现，包括脓疱、大疱、脓肿、丘疹、结节、斑块和溃疡。嗜中性皮病的分类基于嗜中性粒细胞在皮肤中的定位。嗜中性皮病的致病机制涉及自身炎症、嗜中性粒细胞功能障碍、克隆性体细胞突变以及髓系肿瘤中髓系前体细胞的分化。
