Lightman Stafford L
Translational Health Sciences, The Medical School, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK.
J Endocr Soc. 2024 Feb 12;8(4):bvae024. doi: 10.1210/jendso/bvae024. eCollection 2024 Feb 19.
Measurement of blood levels of circulating hormones has always been the cornerstone of the biochemical diagnosis of endocrine diseases, with the objective of detecting hormone excess or insufficiency. Unfortunately, the dynamic nature of hormone secretion means single-point measurements of many hormones often lack diagnostic validity. Endocrinologists have devised complex dynamic tests as indirect assessments of the functioning of the hormone system under investigation. Recent advances in the measurement of dynamic hormone changes across the day now offer an opportunity to reconsider whether there might be better ways both to diagnose and to monitor the therapy of endocrine conditions.
测量循环激素的血液水平一直是内分泌疾病生化诊断的基石，目的是检测激素分泌过多或不足。不幸的是，激素分泌的动态特性意味着对许多激素进行单点测量往往缺乏诊断有效性。内分泌学家设计了复杂的动态测试，作为对所研究激素系统功能的间接评估。目前，在测量一天中动态激素变化方面取得的进展，为重新思考是否可能存在更好的方法来诊断和监测内分泌疾病的治疗提供了契机。
