Rajanna Lohith Banavara, Datta Rakesh, Raina Sheetal, Bayad Himanshu Chhagan, Madakshira Manoj Gopal, Upadhyay Kiran, Tripathi Shailendra, Srivastava Anchita, Chahar Omvir Singh, Singh Ombir
Department of ENT, Head and Neck Surgery, Command Hospital Central Command, Cariappa Road, Lucknow, Uttar Pradesh 226002 India.
Department of Pathology, Command Hospital Central Command, Cariappa Road, Lucknow, Uttar Pradesh 226002 India.
Indian J Otolaryngol Head Neck Surg. 2024 Feb;76(1):88-93. doi: 10.1007/s12070-023-04088-3. Epub 2023 Jul 25.
Glomangiopericytoma (GPC) is a rare benign sinonasal tumor originating from Zimmerman's Pericytes surrounding capillaries and accounting for less than 0.05% of all sinonasal tumors. Glomangiopericytoma has low malignant potential (5-10%) and is mostly diagnosed in the 6th or 7th decade of age with slight female preponderance. We presented here a case series of 5 patients with sinonasal GPC. This research was conducted at a tertiary healthcare centre in North India. In our case series, all the patients were evaluated and underwent endoscopic surgical resection. All patients underwent digital subtraction angiography (DSA) and preoperative embolization. The coblation technique used for haemostasis proved very effective and time-saving. All patients exhibited cytoplasmic SMA positivity (a marker of GPC) and CD34 negativity, while one patient exhibited a high Ki-67 index (> 10%), which is a predictor of aggressive tumor behavior. None of the patients showed any recurrence in follow-up. We recommend performing complete endoscopic surgical excision to prevent recurrence. The use of DSA, preoperative embolization, and intraoperative use of the coblation technique provides a cleaner surgical field and reduced operating time.
血管外皮细胞瘤（GPC）是一种罕见的鼻窦良性肿瘤，起源于围绕毛细血管的齐默尔曼周细胞，占所有鼻窦肿瘤的比例不到0.05%。血管外皮细胞瘤具有低恶性潜能（5%-10%），大多在60或70岁时被诊断出来，女性略占优势。我们在此展示了一组5例鼻窦GPC患者的病例系列。本研究在印度北部的一家三级医疗中心进行。在我们的病例系列中，所有患者均接受了评估并接受了内镜手术切除。所有患者均接受了数字减影血管造影（DSA）和术前栓塞。用于止血的低温等离子消融技术被证明非常有效且节省时间。所有患者均表现出细胞质平滑肌肌动蛋白（SMA）阳性（GPC的标志物）和CD34阴性，而1例患者表现出高Ki-67指数（>10%），这是侵袭性肿瘤行为的一个预测指标。所有患者在随访中均未出现任何复发。我们建议进行完整的内镜手术切除以防止复发。DSA、术前栓塞以及术中使用低温等离子消融技术可提供更清洁的手术视野并缩短手术时间。
