气道异常患儿的肺功能测试与支气管镜检查结果的相关性。

Infant Pulmonary Function Tests in Children with Airway Anomalies and Correlation with Bronchoscopy Findings.

机构信息

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India. Correspondence to: Dr. Kana Ram Jat, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.

出版信息

Indian Pediatr. 2024 May 15;61(5):419-424. Epub 2024 Mar 5.

PMID:38449281

Abstract

OBJECTIVES

To evaluate the role infant pulmonary function tests (Tidal Breathing Flow Volume Loops, TBFVL) in children with airway anomalies and to correlate the TBFVL so obtained with bronchoscopy findings.

METHODS

In this prospective cohort study, we enrolled children aged 0-2 years with airway anomalies and performed TBFVL and bronchoscopy. The primary outcome measure was graphic pattern of TBFVL in laryngomalacia. Secondary outcome measures were types of TBFVL results in various airway anomalies and controls.

RESULTS

Out of 53 children enrolled, 28 (52.3%) had laryngomalacia. Pattern 3 (fluttering of inspiratory limb) was commonest TBFVL pattern in laryngomalacia. Among TBFVL parameters, the ratio of inspiratory time to expiratory time (Ti/Te) and tPTEF/tE was significantly high in children with isolated laryngomalacia compared to controls. At six months of follow-up, TBFVL pattern 1 (normal) became the commonest pattern.

CONCLUSION

A particular type of airway anomaly may have a characteristic graphic pattern in TBFVL and TBFVL pattern may indicate improvement in airway anomalies in follow-up.

摘要

目的

评估婴幼儿肺功能测试（潮气量呼吸流量环，TBFVL）在气道异常患儿中的作用，并将所获得的 TBFVL 与支气管镜检查结果相关联。

方法

在这项前瞻性队列研究中，我们招募了年龄在 0-2 岁之间的气道异常患儿，并进行了 TBFVL 和支气管镜检查。主要观察指标为 TBFVL 在喉软化症中的图形模式。次要观察指标为各种气道异常和对照组的 TBFVL 结果类型。

结果

在纳入的 53 名患儿中，28 名（52.3%）存在喉软化症。喉软化症中最常见的 TBFVL 模式为 3 型（吸气支飘动）。在 TBFVL 参数中，与对照组相比，单纯喉软化症患儿的吸气时间与呼气时间比（Ti/Te）和 tPTEF/tE 显著升高。在 6 个月的随访中，TBFVL 模式 1（正常）成为最常见的模式。