Wan Zhenzhou, Zhang Chiyu
Medical Laboratory of Taizhou Fourth People's Hospital, Taizhou, China.
Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Front Microbiol. 2024 Feb 21;15:1343143. doi: 10.3389/fmicb.2024.1343143. eCollection 2024.
Co-circulation of multiple HIV-1 subtypes in the same high-risk groups leads to the on-going generation of various inter-subtype recombinants, including unique (URFs) and circulating (CRFs) recombinant forms, which brings a new challenge for the prevention and eradication of HIV/AIDS. Identification and prompt reporting of new CRFs will provide not only new insights into the understanding of genetic diversity and evolution of HIV-1, but also an early warning of potential prevalence of these variants. Currently, 140 HIV-1 CRFs have been described; however, their prevalence and clinical importance are less concerned. Apart from the mosaic genomic maps, less other valuable information, including the clinical and demographic data, genomic sequence characteristics, origin and evolutionary dynamics, as well as representative genomic fragments for determining the variants, are available for most of these CRFs. Accompanied with the growing increase of HIV-1 full-length genomic sequences, more and more CRFs will be identified in the near future due to the high recombination potential of HIV-1. Here, we discuss the prevalence and clinical importance of various HIV-1 CRFs and propose how to report and make sense of a new HIV-1 CRF.
多种HIV-1亚型在相同高危人群中的共同流行导致了各种亚型间重组体的持续产生，包括独特重组型（URF）和流行重组型（CRF），这给HIV/AIDS的预防和根除带来了新的挑战。识别并及时报告新的CRF不仅将为理解HIV-1的基因多样性和进化提供新的见解，还将对这些变异体的潜在流行发出早期预警。目前，已描述了140种HIV-1 CRF；然而，它们的流行情况和临床重要性较少受到关注。除了镶嵌基因组图谱外，对于大多数这些CRF，其他有价值的信息较少，包括临床和人口统计学数据、基因组序列特征、起源和进化动态，以及用于确定变异体的代表性基因组片段。随着HIV-1全长基因组序列的不断增加，由于HIV-1的高重组潜力，在不久的将来将鉴定出越来越多的CRF。在此，我们讨论了各种HIV-1 CRF的流行情况和临床重要性，并提出了如何报告和理解一种新的HIV-1 CRF。
