Laboratory of Biology of Tumor and Development, GIGA-Cancer, University of Liège, Liège, Belgium.
Department of Obstetrics and Gynecology, Hôpital de la Citadelle, University of Liège, Liège, Belgium.
Reproduction. 2024 Apr 17;167(5). doi: 10.1530/REP-24-0019. Print 2024 May 1.
The impact of adenomyosis on reproductive health needs to be fully understood. By using a murine model, this study provides novel insights into the nuanced mechanisms associated with fertility challenges and offers a foundation for targeted interventions.
This study investigates the intricate relationship between adenomyosis and reproductive health using a murine model, offering novel insights into this prevalent gynecological disorder. Adenomyosis, characterized by the invasive growth of endometrial tissue into the myometrium, is believed to negatively impact fertility. However, the challenge lies in disentangling this influence, as adenomyosis often coexists with other gynecological diseases. A tamoxifen-induced mice model presents a significant advantage by enabling the specific study of adenomyosis, devoid of confounding influences of concurrent gynecological diseases such as endometriosis. Focusing exclusively on adenomyosis, our study aims to elucidate pathogenic mechanisms underlying fertility issues, focusing on estrous cyclicity, ovarian follicle development, and overall fertility. Our findings uncover disruptions in estrous cyclicity, characterized by an increased duration of time spent in the estrus phase in adenomyosis-induced mice. These disturbances are potentially linked to observed compromised folliculogenesis and the remarkable reduction in litter number and size in mice affected by adenomyosis. Moreover, this study unveils potential drivers of subfertility such as progesterone resistance and altered endometrial receptivity. Within the uteri of mice with adenomyosis, reduced expression of the progesterone receptor and a decreased expression of two implantation-related markers (HoxA10 and integrin β3) were observed. This comprehensive examination sheds light on the nuanced complexities of adenomyosis-associated reproductive challenges, providing a foundation for targeted interventions in addressing fertility issues related to this disease.
需要充分了解腺肌病对生殖健康的影响。本研究通过使用小鼠模型，为与生育挑战相关的微妙机制提供了新的见解，并为有针对性的干预措施奠定了基础。
本研究通过使用小鼠模型研究了腺肌病与生殖健康之间的复杂关系，为这一常见的妇科疾病提供了新的见解。腺肌病的特征是子宫内膜组织侵入子宫肌层，据信会对生育能力产生负面影响。然而，挑战在于理清这种影响，因为腺肌病通常与其他妇科疾病并存。三苯氧胺诱导的小鼠模型具有显著优势，能够专门研究腺肌病，而不会受到子宫内膜异位症等并发妇科疾病的混杂影响。本研究专注于腺肌病，旨在阐明与生育问题相关的发病机制，重点关注动情周期性、卵巢卵泡发育和整体生育能力。我们的研究结果揭示了动情周期性的紊乱，表现为在腺肌病诱导的小鼠中处于发情期的时间延长。这些紊乱可能与观察到的卵泡发生受损以及受腺肌病影响的小鼠的产仔数和大小显著减少有关。此外，本研究揭示了导致生育能力下降的潜在驱动因素，如孕激素抵抗和子宫内膜容受性改变。在患有腺肌病的小鼠的子宫中，孕激素受体的表达减少和两个与着床相关的标志物（HoxA10 和整合素β3）的表达减少。这项全面的研究揭示了腺肌病相关生殖挑战的微妙复杂性，为解决与该疾病相关的生育问题提供了有针对性的干预措施的基础。
