Division of Neonatology, Children's Hospital of Fudan University, China.
Division of Neonatology, Children's Hospital of Fudan University, China.
Clinics (Sao Paulo). 2024 Mar 6;79:100341. doi: 10.1016/j.clinsp.2024.100341. eCollection 2024.
Very Low Birthweight (VLBW) infants with neonatal Chronic Lung Disease (CLD) have been found to have functional impairment of the brainstem auditory pathway at term. This study investigated the functional status of the brainstem auditory pathway in VLBW infants with CLD after term for any abnormality.
Fifty-two VLBW infants were recruited at 50 weeks of Postconceptional Age: 25 with neonatal CLD and 27 without CLD. None had any other major complications to minimize confounding effects. Brainstem Auditory Evoked Responses were studied at 21‒91/s click rates.
Compared with those without CLD, VLBW infants with CLD had relatively shorter latencies of BAER waves I and III, associated with a slightly lower BAER threshold. Wave V latency and I‒V interpeak interval did not differ significantly between the two groups of infants. The I‒III interval in infants with CLD was shorter than in those without CLD at 91/s clicks. However, the III‒V interval was significantly longer than in those without CLD at all click rates (all p < 0.05). There were no significant differences in the amplitudes of BAER wave components between the two groups of infants.
The main BAER abnormality in VLBW infants with CLD was a prolonged III‒V interval. Auditory conduction is delayed or impaired at more central regions of the brainstem in CLD infants. After term central auditory function is adversely affected by neonatal CLD. Monitoring post-term change is required to provide valuable information for post-term care of CLD infants.
患有新生儿慢性肺病（CLD）的极低出生体重（VLBW）婴儿在足月时被发现脑干听觉通路存在功能障碍。本研究旨在调查 CLD 足月后 VLBW 婴儿的脑干听觉通路的功能状态，以确定是否存在任何异常。
52 名 VLBW 婴儿在妊娠 50 周时被招募：25 名患有新生儿 CLD，27 名无 CLD。为了最大限度地减少混杂效应，所有婴儿均无其他重大并发症。在 21‒91/s 的点击率下研究脑干听觉诱发电位。
与无 CLD 的婴儿相比，患有 CLD 的 VLBW 婴儿的脑干听觉诱发电位波 I 和 III 的潜伏期较短，与稍低的脑干听觉诱发电位阈值相关。两组婴儿的波 V 潜伏期和 I‒V 峰间潜伏期无显著差异。在 91/s 的点击率下，CLD 婴儿的 I‒III 间隔短于无 CLD 的婴儿。然而，在所有点击率下，CLD 婴儿的 III‒V 间隔明显长于无 CLD 的婴儿（均 p<0.05）。两组婴儿的脑干听觉诱发电位波成分的振幅无显著差异。
CLD 的 VLBW 婴儿的主要脑干听觉诱发电位异常是 III‒V 间隔延长。CLD 婴儿的听觉传导在脑干更中心区域延迟或受损。足月后，CLD 会对中枢听觉功能产生不利影响。需要监测后期变化，为 CLD 婴儿的后期护理提供有价值的信息。
