认知功能影响多发性硬化症患者双重任务行走中的认知-运动干扰。

Cognitive function influences cognitive-motor interference during dual task walking in multiple sclerosis.

机构信息

Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, 1651 4th street, San Francisco, CA, USA.

Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, 1651 4th street, San Francisco, CA, USA; Department of Physical Therapy and Rehabilitation Science, University of California at San Francisco, San Francisco, CA, USA.

出版信息

Mult Scler Relat Disord. 2024 May;85:105516. doi: 10.1016/j.msard.2024.105516. Epub 2024 Feb 29.

DOI:10.1016/j.msard.2024.105516

PMID:38461729

Abstract

BACKGROUND

Both physical and cognitive impairments are common in people with multiple sclerosis (PwMS). Performing a cognitive task while walking (i.e., dual-task walking) can introduce cognitive-motor interference (CMI), resulting in changes in walking performance. The association between the levels of cognitive impairment and of CMI in MS remains unclear.

OBJECTIVES

To examine the association between cognitive functioning and differences in walking performance arise between single- and dual-task walking.

METHODS

Ninety-five PwMS performed self-preferred pace walking and dual-task walking. The gait parameters recorded were used to compute dual task costs (DTC) as a metric of CMI. Cognitive functioning was assessed using Match, an unsupervised test developed based on the Symbol Digit Modalities Test. Participants were categorized as higher (HCF) and lower cognitive functioning (LCF) based on a Match z-score < -1.5.

RESULTS

LCF group had elevated DTC for stride velocity, relative to the HCF group. Higher DTC for stride velocity was associated with lower cognition, as assessed by Match test.

CONCLUSION

The findings support the hypothesis that CMI is associated with cognitive functioning in PwMS.

摘要

背景

多发性硬化症患者（PwMS）普遍存在身体和认知障碍。在行走时执行认知任务（即双重任务行走）会引入认知-运动干扰（CMI），从而导致行走表现发生变化。MS 患者的认知障碍程度与 CMI 之间的关联尚不清楚。

目的

研究认知功能与单任务行走和双任务行走之间行走表现差异之间的关系。

方法

95 名 PwMS 进行了自我偏好的步速行走和双重任务行走。记录的步态参数用于计算双重任务成本（DTC）作为 CMI 的指标。认知功能使用 Match 进行评估，Match 是一种基于符号数字模态测试开发的无监督测试。根据 Match z 分数 <-1.5 将参与者分为高认知功能（HCF）和低认知功能（LCF）组。