Modi Chetna, Gadhvi Varsha, Prajapati Bhupendra G
Department of Pharmaceutics, Anand Pharmacy College, Anand, Gujarat, India.
Shree S.K.Patel College of Pharmaceuticals Education and Research, Ganpat University, India.
Pharm Nanotechnol. 2024 Mar 8. doi: 10.2174/0122117385286925240221111601.
Due to the complexities of the eye's anatomy and physiology, achieving targeted drug delivery with minimal harm to healthy eye tissues has proven to be difficult. The focus of the review is on the potential of lipid and polymer micelle-based drug delivery systems, specifically nanomicelles, to overcome these challenges and improve the absorption of insoluble drugs. Nanomicelles offer several advantages, such as enhanced drug release kinetics, increased drug incorporation, and improved formulation of hydrophobic medicines. The review provides insights into various excipients, preparation methods, and evaluation techniques used in nanomicellar-based drug delivery systems. Furthermore, the review highlights current research and patents related to nanomicelles in ocular drug delivery, suggesting growing interest and potential for future developments in this field. Nanomicelles present a promising approach that may revolutionize ocular drug delivery and open new possibilities for treating various ocular diseases while minimizing adverse effects on healthy eye tissues.
由于眼睛解剖学和生理学的复杂性,在对健康眼组织造成最小伤害的情况下实现靶向药物递送已被证明是困难的。本综述的重点是基于脂质和聚合物的胶束药物递送系统,特别是纳米胶束,克服这些挑战并改善不溶性药物吸收的潜力。纳米胶束具有几个优点,如增强的药物释放动力学、增加的药物包封率以及改善的疏水药物制剂。本综述深入探讨了纳米胶束药物递送系统中使用的各种辅料、制备方法和评估技术。此外,该综述强调了与纳米胶束在眼部药物递送方面相关的当前研究和专利,表明该领域的兴趣日益浓厚且未来发展潜力巨大。纳米胶束提出了一种有前景的方法,可能会彻底改变眼部药物递送,并为治疗各种眼部疾病开辟新的可能性,同时将对健康眼组织的不良影响降至最低。