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在减轻 中电离辐射诱导损伤方面的多方面作用。

's multifaceted role in mitigating ionizing radiation-induced injury in .

机构信息

Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, P.R. China.

出版信息

Food Funct. 2024 Apr 2;15(7):3522-3538. doi: 10.1039/d3fo05422e.

Abstract

The numerous beneficial probiotic properties of () include decreasing metabolic syndrome, preventing disorders linked to oxidative stress, improving gut flora imbalances, controlling immunological function, and extending life span. Exposure to ionizing radiation is closely associated with several disorders. We examined the protective and salvaging effects of on ionizing radiation-induced injury to the intestinal tract, reproductive system, and nervous system of . We also examined its effects on lifespan, antioxidant capacity, progeny development, and behavioral aspects to assess the interaction between and ionizing radiation-induced injury. The findings demonstrated that improved the median survival time following irradiation and greatly extended its lifespan. In addition, it raised SOD activity, reduced ROS levels in intestinal epithelial cells, and increased the quantity of intestinal stem cells. Furthermore, enhanced the adult male flies' capacity to move. It also successfully safeguarded the generations' growth and development. dramatically enhanced expression of the AMPKα gene and regulated expression of its pathway-related gene, mTOR, as well as the autophagy-related genes Atg1 and Atg5 in female exposed to irradiation. Notably, no prior reports have been made on the possible effects of on injuries caused by irradiation. As a result, our research offers important new information regarding 's possible role as a shield against ionizing radiation-induced injury.

摘要

()的许多有益的益生菌特性包括降低代谢综合征、预防与氧化应激相关的疾病、改善肠道菌群失衡、控制免疫功能和延长寿命。电离辐射的暴露与多种疾病密切相关。我们研究了()对电离辐射诱导的肠道、生殖系统和神经系统损伤的保护和挽救作用。我们还研究了它对寿命、抗氧化能力、后代发育和行为方面的影响,以评估()与电离辐射诱导损伤之间的相互作用。研究结果表明,()提高了照射后的中位生存时间,并大大延长了其寿命。此外,它提高了 SOD 活性,降低了肠道上皮细胞中的 ROS 水平,并增加了肠道干细胞的数量。此外,()增强了雄性成年果蝇的运动能力。它还成功地保护了后代的生长和发育。()显著增强了照射后雌性果蝇 AMPKα 基因的表达,并调节了其通路相关基因 mTOR 以及自噬相关基因 Atg1 和 Atg5 的表达。值得注意的是,之前没有关于()对辐射损伤可能影响的报道。因此,我们的研究为()在防止电离辐射诱导损伤方面可能发挥的作用提供了重要的新信息。

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