感觉特征及其在腰痛中枢敏化症状持续存在中的作用。一项前瞻性队列研究。

Sensory profiles and their role in the persistence of central sensitization symptoms in low back pain. A prospective cohort study.

作者信息

Gräper Pieter J, Hartvigsen Jan, Scafoglieri Aldo, Clark Jacqueline R, van Trijffel Emiel, Hallegraeff Joannes M

机构信息

Faculty of Physical Education and Physiotherapy, Department of Physiotherapy, Human Physiology and Anatomy, Experimental Anatomy research group, Vrije Universiteit Brussel, Brussels, Belgium.

Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.

出版信息

Physiother Theory Pract. 2025 Feb;41(2):317-326. doi: 10.1080/09593985.2024.2326592. Epub 2024 Mar 11.

DOI:10.1080/09593985.2024.2326592

PMID:38466052

Abstract

INTRODUCTION

Acute lower back pain can lead to neuroplastic changes in the central nervous system, and symptoms of central sensitization after 12 weeks. While sensory sensitivity has been shown to predict symptoms of central sensitization, trait sensory profiles may be prognostic in the persistence of central sensitization symptoms in low back pain over time.

OBJECTIVE

To examine sensory profiles as prognostic symptoms of central sensitization in people with acute low back pain.

METHODS

A longitudinal type 2 prognostic factor research study was performed according to the PROGRESS framework. Baseline and 12-week follow-up measures were taken using the Adolescent/Adult Sensory Profile and the Central Sensitization Inventory measures. Study participants were consecutively included from primary care physiotherapy practices. Univariable, and multivariable regression analyses were performed to adjust sensory profiles based on previous history of low back pain, baseline Central Sensitization Inventory scores, level of pain, disability, age, and duration of low back pain.

RESULTS

After adjustment, the sensory profiles of Low Registration B = 0.44, 95%CI (0.18, 0.70), Sensation Seeking B = 0.38, 95%CI (0.19, 0.57), Sensory Sensitive B = 0.49, 95%CI (0.25, 0.74), Sensation Avoiding B = 0.40, 95% CI (0.15, 0.65) was significantly associated with the persistence of central sensitization symptoms ( = 103).

CONCLUSION

Sensory profiles may predict symptoms of central sensitization after 12 weeks in people with acute low back pain.

摘要

引言

急性下背痛可导致中枢神经系统发生神经可塑性变化，并在12周后出现中枢敏化症状。虽然感觉敏感性已被证明可预测中枢敏化症状，但特质感觉特征可能对下背痛中枢敏化症状的持续存在具有预后价值。

目的

研究感觉特征作为急性下背痛患者中枢敏化的预后症状。

方法

根据PROGRESS框架进行了一项纵向2型预后因素研究。使用青少年/成人感觉特征量表和中枢敏化量表进行基线和12周随访测量。研究参与者连续纳入初级保健物理治疗诊所。进行单变量和多变量回归分析，以根据既往下背痛病史、基线中枢敏化量表评分、疼痛程度、残疾程度、年龄和下背痛持续时间调整感觉特征。

结果

调整后，低登记（Low Registration）B = 0.44，95%置信区间（CI）（0.18，0.70）；寻求感觉（Sensation Seeking）B = 0.38，95%CI（0.19，0.57）；感觉敏感（Sensory Sensitive）B = 0.49，95%CI（0.25，0.74）；避免感觉（Sensation Avoiding）B = 0.40，95%CI（0.15，0.65）与中枢敏化症状的持续存在显著相关（n = 103）。