Swanson Allyson J, Rogowski Victor J, Bishop Jacob A, Walker Dylan M, Roxas Gina M, Raimondi Stacey L
Department of Biology, Elmhurst University, Elmhurst, Illinois, United States of America.
Department of Chemistry and Biochemistry, Elmhurst University, Elmhurst, Illinois, United States of America.
PLoS One. 2024 Mar 11;19(3):e0300477. doi: 10.1371/journal.pone.0300477. eCollection 2024.
Acute myeloid leukemia (AML) is an aggressive and lethal cancer of the blood, which leads to the death of over 11,000 patients in the United States each year. Research on identifying, characterizing, and treating AML is crucial in the fight against this deadly disease. Recent studies have examined the role of CLEC11A in cancer, including AML. However, there have been conflicting reports related to tumor progression and survival. Because survival is based on a variety of factors, including classification of the tumor, genetic risk factors, and demographics, it is imperative that we determine what role CLEC11A may have in cancer survival. Therefore, utilizing data from the Genomic Data Commons, we analyzed CLEC11A methylation in 108 AML patients compared to FAB classification, cytogenetic risk factors, age, race, and gender. Our results show statistically significant correlations between methylation of CLEC11A and FAB classification as well as poor genetic risk factors. However, no difference was observed in CLEC11A methylation when compared to demographic data. Our results, matched with a known biological function of CLEC11A in early hematopoiesis, indicate that CLEC11A may be an important marker for AML diagnosis and prognosis and provide relevant data in the ongoing search for novel therapeutics to improve AML survival.
急性髓系白血病（AML）是一种侵袭性致命血液癌症，在美国每年导致超过11000名患者死亡。识别、表征和治疗AML的研究对于抗击这种致命疾病至关重要。最近的研究探讨了CLEC11A在癌症（包括AML）中的作用。然而，关于肿瘤进展和生存的报道存在矛盾。由于生存取决于多种因素，包括肿瘤分类、遗传风险因素和人口统计学特征，因此我们必须确定CLEC11A在癌症生存中可能发挥的作用。因此，利用基因组数据共享库的数据，我们分析了108例AML患者中CLEC11A的甲基化情况，并与FAB分类、细胞遗传学风险因素、年龄、种族和性别进行了比较。我们的结果显示，CLEC11A甲基化与FAB分类以及不良遗传风险因素之间存在统计学上的显著相关性。然而，与人口统计学数据相比，CLEC11A甲基化未观察到差异。我们的结果与CLEC11A在早期造血中的已知生物学功能相匹配，表明CLEC11A可能是AML诊断和预后的重要标志物，并为正在进行的寻找改善AML生存的新型疗法的研究提供相关数据。
