Department of Laboratory Science, School of Medicine, Islamic Azad University, Babol Branch, Babol, Iran.
Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Infect Disord Drug Targets. 2024;24(8):e110324227851. doi: 10.2174/0118715265276270240222070244.
Malaria is still the deadliest parasitic disease caused by Plasmodium spp. Due to drug resistance and their unpleasant side effects, of conventional researchers are enormously seeking to achieve antimalarial drugs with more curative effective, less toxic and cost-affordable drugs using more advanced technology such as nanodrugs.
The present study aimed to examine the antimalarial effects of a novel synthesized nonochloroquine-loaded curcumin relying on dendrimer G2 in susceptible mice.
Antimalarial activity and toxicity of the nanocomposite were examined on BALB/C mice with microscopy, checking RBCs morphology and related enzymatic activity rate.
The maximum inhibitory effect of the nanocomposite was seen at 10 mg/kg, killing 98% of compared to sole chloroquine, whereas ED50 was reported at 5.5 mg/kg. The safety of the synthesized nanocomposite was confirmed with biochemical tests with no detrimental effects on mice. The sustainability and longevity of the nanodrug increased significantly with the NDC-CQ assay compared to the control groups.
The study showed that nonochloroquine-loaded curcumin had a promising inhibitory effect on growth in infected mice compared to standard drugs. However, further studies and clinical trials with large samples are recommended to study different aspects of using nanodrug.
疟疾仍然是由疟原虫引起的最致命的寄生虫病。由于耐药性和不良反应，传统的研究人员正在极大地寻求具有更有效治疗效果、毒性更小和更经济实惠的药物，他们正在利用更先进的技术，如纳米药物。
本研究旨在研究新型合成的载有氯喹的姜黄素负载树状大分子 G2 纳米复合物在易感小鼠中的抗疟作用。
通过显微镜检查、检查 RBC 形态和相关酶活性率，研究了纳米复合材料的抗疟活性和毒性。
纳米复合材料的最大抑制作用在 10mg/kg 时出现，与单独使用氯喹相比，杀死了 98%的疟原虫，而 ED50 为 5.5mg/kg。生化试验证实了合成纳米复合材料的安全性，对小鼠没有不良影响。与对照组相比，NDC-CQ 测定法显著提高了纳米药物的可持续性和长效性。
该研究表明，与标准药物相比，载有氯喹的姜黄素对感染小鼠的生长具有有希望的抑制作用。然而，建议进行进一步的研究和临床试验，以研究纳米药物的不同方面。
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