Ravi Ananya, DeMarco Elisabeth C, Gebauer Sarah, Poirier Michael P, Hinyard Leslie J
Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.
Department of Health and Clinical Outcomes Research, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.
Healthcare (Basel). 2024 Feb 20;12(5):502. doi: 10.3390/healthcare12050502.
Osteoarthritis (OA) is the most common joint disease in the US and can increase the risk of depression. Both depression and OA disproportionately affect women, yet this study is one of few on depression prevalence, treatment across age groups, and predictors in women with OA. Data were extracted from the 2011-March 2020 National Health and Nutrition Examination Survey (NHANES). Women aged ≥ 45 years with self-reported osteo- or degenerative arthritis were included. Outcomes were depression (assessed with PHQ-9) and treatment (self-reported pharmacotherapy and mental health services). Logistic regression was used to examine associations between age group, covariates, and outcomes. Overall, depression prevalence was 8%, with higher proportions among those 45-64 years old. Aging was associated with reduced odds of depression (Age 65-79: OR 0.68 (95% CI: 0.52-0.89); Age 80+: OR 0.49 (95% CI: 0.33-0.74); vs. Age 45-54). Of those with a positive depression screen, 21.6% documented some form of treatment. Age group was not statistically different between those treated and those not treated. Women aged 45-64 with osteoarthritis may be at increased risk of depression, and most are not treated. As depression is related to increased pain and risk of rehospitalization, future research should prioritize interventions to increase uptake of depression treatment.
骨关节炎（OA）是美国最常见的关节疾病，会增加患抑郁症的风险。抑郁症和骨关节炎对女性的影响尤为严重，但这项研究是为数不多的关于抑郁症患病率、各年龄组治疗情况以及骨关节炎女性患者预测因素的研究之一。数据来自2011年3月至2020年的美国国家健康与营养检查调查（NHANES）。纳入了年龄≥45岁且自我报告患有骨关节炎或退行性关节炎的女性。研究结果包括抑郁症（用PHQ-9评估）和治疗情况（自我报告的药物治疗和心理健康服务）。采用逻辑回归分析来研究年龄组、协变量与研究结果之间的关联。总体而言，抑郁症患病率为8%，45至64岁人群中的患病率更高。年龄增长与抑郁症患病几率降低相关（65至79岁：比值比0.68（95%置信区间：0.52至0.89）；80岁及以上：比值比0.49（95%置信区间：0.33至0.74）；与45至54岁相比）。在抑郁症筛查呈阳性的患者中，21.6%记录了某种形式的治疗。接受治疗和未接受治疗的患者在年龄组上没有统计学差异。45至64岁患有骨关节炎的女性可能患抑郁症的风险更高，且大多数未接受治疗。由于抑郁症与疼痛加剧和再次住院风险增加有关，未来的研究应优先考虑采取干预措施，以提高抑郁症治疗的接受率。
