Queen Victoria Hospital NHS Foundation Trust, East Grinstead, United Kingdom.
Queen Victoria Hospital NHS Foundation Trust, East Grinstead, United Kingdom.
Burns. 2024 Jun;50(5):1045-1052. doi: 10.1016/j.burns.2024.02.024. Epub 2024 Mar 1.
Infections are a major cause of morbidity and mortality in burn patients, and the rise of multidrug-resistant organisms (MDROs) has made it more challenging to manage and prevent infections. This review examines the available treatment options for MDROs in burn patients and anticipates the future challenges posed by their increasing prevalence. The review covers new antibiotics, such as Eravacycline and Plazomicin, as well as non-antibiotic therapies, such as bacteriophages and nanoparticles. Future research should focus on examining the long-term efficacy, cost-effectiveness, and in vivo efficacy of different treatment modalities. The potential of alternative therapies, such as probiotics and low-frequency magnetic fields, should also be explored. Accurate and rapid diagnostic and monitoring tools for detecting MDROs in burn patients should be developed. The emergence of MDROs in burn care is a challenge and a new beginning in infection innovation and novel treatments.
感染是烧伤患者发病率和死亡率的主要原因，而多药耐药菌（MDROs）的出现使得管理和预防感染更加具有挑战性。本综述探讨了目前用于烧伤患者 MDROs 的治疗选择，并预测了其日益流行所带来的未来挑战。该综述涵盖了新的抗生素，如依拉环素和普拉佐米星，以及非抗生素疗法，如噬菌体和纳米颗粒。未来的研究应集中在检查不同治疗方式的长期疗效、成本效益和体内疗效上。还应探索替代疗法的潜力，如益生菌和低频磁场。应开发用于烧伤患者中检测 MDROs 的准确和快速的诊断和监测工具。MDROs 在烧伤护理中的出现既是挑战，也是感染创新和新型治疗的新起点。
