Merkel 细胞癌酷似急性白血病。

Merkel cell carcinoma mimicking acute leukemia.

机构信息

DynaLIFE Medical Labs, Edmonton, Alberta, Canada.

Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, Canada.

出版信息

Int J Lab Hematol. 2024 Oct;46(5):761-763. doi: 10.1111/ijlh.14262. Epub 2024 Mar 13.

DOI:10.1111/ijlh.14262

PMID:38477102

Abstract

Bone marrow aspirate showed diffuse infiltration by a population of monomorphic cells with scant cytoplasm, markedly increased nuclear-to-cytoplasmic ratio, and numerous indistinct nucleoli. Bone marrow biopsy confirmed extensive marrow infiltration by a malignant neoplasm with strong and diffuse expression of synaptophysin by immunohistochemistry, consistent with metastases from Merkel Cell carcinoma.

摘要

骨髓穿刺显示，骨髓中弥漫浸润着一群形态单一的细胞，细胞浆稀少，核浆比显著增高，且有许多不明显的核仁。骨髓活检证实恶性肿瘤广泛浸润骨髓，免疫组织化学染色显示突触素强而弥漫表达，与 Merkel 细胞癌转移一致。