Department of Pathology, ASST Grande Ospedale Niguarda, Milan, Italy.
Postgraduate School of Pathology, University of Milan, Milan, Italy.
Pathologica. 2024 Feb;116(1):13-21. doi: 10.32074/1591-951X-957.
The WHO Classification of Tumors, Thoracic Tumors, 5th edition, has outlined the use of TTF-1 and ΔNP63/P40 to discriminate between adenocarcinoma and squamous cell carcinoma. In 2015, the first description of a rare non-small cell lung carcinoma featuring co-expression of glandular and squamous differentiation within most of the same individual tumor cells was reported on, with ultrastructural and molecular demonstration of such a biphenotypic differentiation. We herein describe an additional case of this rare tumor entity, which is confirmed to be an aggressive neoplasm despite potential targets of therapy.
世界卫生组织（WHO）第 5 版《肿瘤分类：胸部肿瘤》中，已概述了使用 TTF-1 和 ΔNP63/P40 来区分腺癌和鳞状细胞癌。2015 年，首次报道了一种罕见的非小细胞肺癌，其在同一肿瘤细胞的大部分中表现出腺和鳞状分化的共表达，并通过超微结构和分子研究证实了这种双表型分化。本文描述了该罕见肿瘤实体的另一个病例，尽管存在潜在的治疗靶点，但该肿瘤被证实为侵袭性肿瘤。
