From the Department of Obstetrics and Gynecology; University of Alabama at Birmingham, Birmingham, AL.
Urogynecology (Phila). 2024 Mar 1;30(3):239-244. doi: 10.1097/SPV.0000000000001457. Epub 2024 Jan 11.
Recurrent urinary tract infections (rUTIs) affect 2-10% of adult women and are associated with a significant effect on quality of life, daily activities, and mental health.
The aim of this study was to identify clinical characteristics associated with rUTIs among women seeking care for pelvic floor disorders at an academic tertiary urogynecology clinic.
A retrospective case-control study of women presenting to an academic tertiary urogynecology clinic was conducted. Cases were women with rUTIs, defined as ≥2 UTIs in 6 months or ≥3 within 1 year. Controls were women with no culture documented UTIs. Cases were matched 2:1 to controls by age and body mass index. Demographic and clinical characteristics were compared between cases and controls, and bivariate characteristics with P values ≤0.2 were assessed for an independent association with rUTIs by multivariable logistic regression.
A total of 285 cases with rUTIs were identified, and 150 matched controls had a mean (SD) age of 72 (11.8) years and a body mass index of 29.6 (6.7; calculated as weight in kilograms divided by height in meters squared). Multivariable analysis revealed that prolapse beyond the introitus (odds ratio [OR], 0.28; 95% confidence interval [CI], 0.13-0.60), parity (OR, 1.33; 95% CI, 1.08-1.64), Charlson Comorbidity Index (OR, 1.66; 95% CI, 1.37-2.03), and postvoid residual volume ≥100 mL (OR, 4.05; 95% CI, 2.01, 8.18) were associated with rUTIs.
In this ambulatory urogynecologic population, prolapse through the introitus was negatively associated with rUTIs, whereas parity, increased medical comorbidities, and elevated postvoid residual volume were positively associated with rUTI. Future research should seek an increased understanding of these factors associated with rUTI to implement effective preventive strategies.
复发性尿路感染（rUTIs）影响 2-10%的成年女性，对生活质量、日常活动和心理健康有显著影响。
本研究旨在确定在学术三级泌尿妇科诊所就诊的女性中与 rUTIs 相关的临床特征。
对在学术三级泌尿妇科诊所就诊的女性进行了回顾性病例对照研究。病例为 rUTIs 患者，定义为 6 个月内≥2 次尿路感染或 1 年内≥3 次尿路感染。对照组为无培养记录的尿路感染女性。病例按年龄和体重指数与对照组 2:1 匹配。比较病例与对照组之间的人口统计学和临床特征，并通过多变量逻辑回归评估 P 值≤0.2 的二变量特征与 rUTIs 的独立相关性。
共确定了 285 例 rUTIs 病例，150 例匹配对照的平均（SD）年龄为 72（11.8）岁，体重指数为 29.6（6.7；体重以千克为单位除以身高以米为单位计算）。多变量分析显示，阴道入口外脱垂（比值比 [OR]，0.28；95%置信区间 [CI]，0.13-0.60）、产次（OR，1.33；95% CI，1.08-1.64）、Charlson 合并症指数（OR，1.66；95% CI，1.37-2.03）和残余尿量≥100 mL（OR，4.05；95% CI，2.01，8.18）与 rUTIs 相关。
在这个门诊泌尿妇科人群中，阴道入口外脱垂与 rUTIs 呈负相关，而产次、合并症增多和残余尿量增加与 rUTI 呈正相关。未来的研究应寻求对这些与 rUTI 相关的因素有更深入的了解，以实施有效的预防策略。
