Zhang Hongzhou, Leng Shuang, Gao Fei, Kovalik Jean-Paul, Wee Hai Ning, Chua Kee Voon, Ching Jianhong, Allen John C, Zhao Xiaodan, Tan Ru-San, Wu Qinghua, Leiner Tim, Koh Angela S, Zhong Liang
Department of Cardiovascular Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.
Front Cardiovasc Med. 2024 Feb 29;11:1346443. doi: 10.3389/fcvm.2024.1346443. eCollection 2024.
Pulmonary artery (PA) strain is associated with structural and functional alterations of the vessel and is an independent predictor of cardiovascular events. The relationship of PA strain to metabolomics in participants without cardiovascular disease is unknown.
In the current study, community-based older adults, without known cardiovascular disease, underwent simultaneous cine cardiovascular magnetic resonance (CMR) imaging, clinical examination, and serum sampling. PA global longitudinal strain (GLS) analysis was performed by tracking the change in distance from the PA bifurcation to the pulmonary annular centroid, using standard cine CMR images. Circulating metabolites were measured by cross-sectional targeted metabolomics analysis.
Among = 170 adults (mean age 71 ± 6.3 years old; 79 women), mean values of PA GLS were 16.2 ± 4.4%. PA GLS was significantly associated with age (= -0.13, = 0.017), heart rate (=-0.08, = 0.001), dyslipidemia (=-2.37, = 0.005), and cardiovascular risk factors (=-2.49, = 0.001). Alanine (=-0.007, = 0.01) and proline (=-0.0009, = 0.042) were significantly associated with PA GLS after adjustment for clinical risk factors. Medium and long-chain acylcarnitines were significantly associated with PA GLS (C12, = 0.027; C12-OH/C10-DC, = 0.018; C14:2, = 0.036; C14:1, = 0.006; C14, = 0.006; C14-OH/C12-DC, = 0.027; C16:3, = 0.019; C16:2, = 0.006; C16:1, = 0.001; C16:2-OH, = 0.016; C16:1-OH/C14:1-DC, = 0.028; C18:1-OH/C16:1-DC, = 0.032).
By conventional CMR, PA GLS was associated with aging and vascular risk factors among a contemporary cohort of older adults. Metabolic pathways involved in PA stiffness may include gluconeogenesis, collagen synthesis, and fatty acid oxidation.
肺动脉（PA）应变与血管的结构和功能改变相关，并且是心血管事件的独立预测因子。PA应变与无心血管疾病参与者的代谢组学之间的关系尚不清楚。
在本研究中，无已知心血管疾病的社区老年成年人同时接受了电影心血管磁共振（CMR）成像、临床检查和血清采样。使用标准电影CMR图像，通过追踪从PA分叉到肺环质心的距离变化来进行PA整体纵向应变（GLS）分析。通过横断面靶向代谢组学分析测量循环代谢物。
在170名成年人（平均年龄71±6.3岁；79名女性）中，PA GLS的平均值为16.2±4.4%。PA GLS与年龄（r = -0.13，P = 0.017）、心率（r = -0.08，P = 0.001）、血脂异常（r = -2.37，P = 0.005）和心血管危险因素（r = -2.49，P = 0.001）显著相关。在调整临床危险因素后，丙氨酸（r = -0.007，P = 0.01）和脯氨酸（r = -0.0009，P = 0.04）与PA GLS显著相关。中链和长链酰基肉碱与PA GLS显著相关（C12，r = 0.027；C12-OH/C10-DC，r = 0.018；C14:2，r = 0.036；C14:1，r = 0.006；C14，r = 0.006；C14-OH/C12-DC，r = 0.027；C16:3，r = 0.019；C16:2，r = 0.006；C16:1，r = 0.001；C16:2-OH，r = 0.016；C16:1-OH/C14:1-DC，r = 0.
