放射性标记的4-壬基酚在小鼠体内的生物累积与追踪
Bioaccumulation and tracking of radiolabeled 4-nonylphenol in mice.
作者信息
Mushtaq Sajid, Kim Soyeon, Bibi Iqra, Park Ji Ae, Yang Ji-Ung, Park Hyun, Kim Jung Young
机构信息
Division of Applied RI, Korea Institute of Radiological & Medical Sciences 75 Nowon-ro, Nowon-gu Seoul 01812 Republic of Korea
Department of Nuclear Engineering, Pakistan Institute of Engineering and Applied Sciences P. O. Nilore Islamabad 45650 Pakistan.
出版信息
RSC Adv. 2024 Mar 14;14(12):8578-8582. doi: 10.1039/d3ra08743c. eCollection 2024 Mar 6.
4-Nonylphenol (4NP) is concerning due to its growing presence and endocrine-disrupting nature, raising concerns about its impact on health. In this study I-labeled 4NP was synthesized for tracing. Positron emission tomography imaging and biodistribution studies showed significant accumulation in various tissues after oral or intraperitoneal administration, emphasizing its intricate distribution and potential long-term effects, crucial for future risk assessments.
4-壬基酚（4NP）因其日益增加的存在及其内分泌干扰特性而令人担忧，这引发了人们对其对健康影响的关注。在本研究中，合成了用于追踪的碘标记4NP。正电子发射断层扫描成像和生物分布研究表明，口服或腹腔注射后，4NP在各种组织中显著蓄积，这突出了其复杂的分布情况和潜在的长期影响，对未来的风险评估至关重要。
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