Zhang Chengfu, Qiu Mengsheng, Fu Hui
Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China.
Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
Neural Regen Res. 2024 Oct 1;19(10):2132-2143. doi: 10.4103/1673-5374.392854. Epub 2024 Jan 8.
Cytokines including tumor necrosis factor, interleukins, interferons, and chemokines are abundantly produced in various diseases. As pleiotropic factors, cytokines are involved in nearly every aspect of cellular functions such as migration, survival, proliferation, and differentiation. Oligodendrocytes are the myelin-forming cells in the central nervous system and play critical roles in the conduction of action potentials, supply of metabolic components for axons, and other functions. Emerging evidence suggests that both oligodendrocytes and oligodendrocyte precursor cells are vulnerable to cytokines released under pathological conditions. This review mainly summarizes the effects of cytokines on oligodendrocyte lineage cells in central nervous system diseases. A comprehensive understanding of the effects of cytokines on oligodendrocyte lineage cells contributes to our understanding of central nervous system diseases and offers insights into treatment strategies.
包括肿瘤坏死因子、白细胞介素、干扰素和趋化因子在内的细胞因子在多种疾病中大量产生。作为多效性因子，细胞因子几乎参与细胞功能的各个方面，如迁移、存活、增殖和分化。少突胶质细胞是中枢神经系统中形成髓鞘的细胞，在动作电位传导、为轴突提供代谢成分及其他功能中起关键作用。新出现的证据表明，少突胶质细胞和少突胶质前体细胞都易受病理条件下释放的细胞因子的影响。本综述主要总结了细胞因子对中枢神经系统疾病中少突胶质细胞谱系细胞的影响。全面了解细胞因子对少突胶质细胞谱系细胞的影响有助于我们理解中枢神经系统疾病，并为治疗策略提供见解。
