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肾移植候选者的癌前病变

Premalignant Lesions in the Kidney Transplant Candidate.

作者信息

Schroder Paul M, Biesterveld Ben E, Al-Adra David P

机构信息

Department of Surgery, Division of Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, WI.

Department of Surgery, Division of Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, WI.

出版信息

Semin Nephrol. 2024 Jan;44(1):151495. doi: 10.1016/j.semnephrol.2024.151495. Epub 2024 Mar 15.

Abstract

End-stage kidney disease patients who are referred for transplant undergo an extensive evaluation process to ensure their health prior to transplant due in part to the shortage of available organs. Although management and surveillance guidelines exist for malignancies identified in the transplant and waitlist populations, less is written about the management of premalignant lesions in this population. This review covers the less common premalignant lesions (intraductal papillary mucinous neoplasm, gastrointestinal stromal tumor, thymoma, and pancreatic neuroendocrine tumor) that can be found in the transplant candidate population. High-level evidence for the management of these rarer premalignant lesions in the transplant population is lacking, and this review extrapolates evidence from the general population and should not be a substitute for a multidisciplinary discussion with medical and surgical oncologists.

摘要

由于可用器官短缺,被转诊进行移植的终末期肾病患者在移植前要接受广泛的评估过程,以确保其健康状况。尽管针对移植人群和等待名单人群中发现的恶性肿瘤已有管理和监测指南,但关于该人群中癌前病变的管理却鲜有论述。本综述涵盖了在移植候选人群中可能发现的较不常见的癌前病变(导管内乳头状黏液性肿瘤、胃肠道间质瘤、胸腺瘤和胰腺神经内分泌肿瘤)。目前缺乏关于移植人群中这些较罕见癌前病变管理的高级别证据,本综述从普通人群中推断证据,不应替代与医学肿瘤学家和外科肿瘤学家进行的多学科讨论。

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