Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
Bull Exp Biol Med. 2024 Feb;176(4):505-508. doi: 10.1007/s10517-024-06056-5. Epub 2024 Mar 16.
The expression of the gene of pattern recognition receptor TLR2, proinflammatory cytokine IL-1β, and anti-inflammatory cytokine IL-10 was analyzed in the peripheral blood of nonagenarians (n=219; mean age 92.1 years, 77 men and 142 women) in comparison with healthy young donors (n=24; mean age 22.5 years, 16 women and 8 men). Nonagenarians were interviewed, medical records were analyzed, and a comprehensive geriatric assessment was performed according to the Clinical Guidelines on Frailty. The level of gene expression was determined by real-time PCR. The participation of inflammatory mechanisms in the immunosenescence was revealed. It was shown that increased expression of IL1B and TLR2 genes is associated with the development of frailty in nonagenarians and can be a factor of pathological aging. Increased expression of IL10 gene can be considered as a factor of successful aging in nonagenarians.
我们分析了 219 名 90 岁以上老人（平均年龄 92.1 岁，77 名男性和 142 名女性）和 24 名健康年轻供体（平均年龄 22.5 岁，16 名女性和 8 名男性）外周血中模式识别受体 TLR2、促炎细胞因子 IL-1β 和抗炎细胞因子 IL-10 的基因表达。我们对 90 岁以上老人进行了访谈、分析了病历并根据临床虚弱指南进行了全面的老年评估。通过实时 PCR 确定基因表达水平。结果表明，IL1B 和 TLR2 基因的高表达与 90 岁以上老人的虚弱发生有关，可能是病理性衰老的一个因素。IL10 基因的高表达可被视为 90 岁以上老人成功衰老的一个因素。
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