Klimov A N, Vinogradov A G, Nagornev V A
Arkh Patol. 1979;41(7):61-8.
The features of impaired permeability of endothelium and increased pinocytosis of endothelial cells in developing experimental atherosclerosis in rabbits are described on the basis of electron microscopy findings. Foam cells of various degrees of vacuolation were recovered from the tissue of atherosclerotic aorta by enzymatic treatment. The stages of smooth muscle cell transformation into foam cells were followed. An analysis of morphological changes occurring in foam cells in response to lipids is given. Interactions of intracellular lipid vacuoles with lysosomes are analysed. Possible causes and modes of impairment of the structure and function of aorta cells in experimental atherosclerosis are discussed.
基于电子显微镜检查结果，描述了家兔实验性动脉粥样硬化发展过程中内皮通透性受损和内皮细胞胞饮作用增加的特征。通过酶处理从动脉粥样硬化主动脉组织中回收了不同程度空泡化的泡沫细胞。追踪了平滑肌细胞转化为泡沫细胞的阶段。对泡沫细胞中因脂质而发生的形态变化进行了分析。分析了细胞内脂质空泡与溶酶体的相互作用。讨论了实验性动脉粥样硬化中主动脉细胞结构和功能受损的可能原因及方式。
