甲醛调节一碳代谢和表观遗传学。

Formaldehyde regulates one-carbon metabolism and epigenetics.

机构信息

University of Lausanne (UNIL), Epalinges, 1010, Switzerland.

Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, 1015, Switzerland.

出版信息

Trends Genet. 2024 May;40(5):381-382. doi: 10.1016/j.tig.2024.03.002. Epub 2024 Mar 18.

DOI:10.1016/j.tig.2024.03.002

PMID:38503578

Abstract

Recently, Pham et al. used an array of model systems to uncover a role for the enzyme methionine adenosyltransferase (MAT)-1A, which is mainly expressed in liver, in both sensing formaldehyde and regulating transcriptional responses that protect against it. This provides a new lens for understanding the effects of formaldehyde on gene regulation.

摘要

最近，Pham 等人利用一系列模型系统揭示了主要在肝脏中表达的酶蛋氨酸腺苷转移酶（MAT）-1A 在感知甲醛和调节转录反应以抵御甲醛方面的作用。这为理解甲醛对基因调控的影响提供了一个新的视角。