利用10年回顾性数据研究一家三级医院中早产儿视网膜病变的发病率及相关危险因素。
The incidence and risk factors associated with the retinopathy of prematurity in a tertiary hospital using 10-year retrospective data.
作者信息
Srimanan Worapot, Kitsirilarp Warissara
机构信息
Ophthalmology Division, Phramongkutklao Hospital.
出版信息
Ann Clin Epidemiol. 2023 Apr 8;5(3):80-87. doi: 10.37737/ace.23011. eCollection 2023.
BACKGROUND
The study aimed to examine the incidence and risk factors associated with retinopathy of prematurity at Phramongkutklao Hospital.
METHODS
A retrospective review was conducted on the medical records of premature infants screened for retinopathy of prematurity between January 2011 and December 2021. The screening examination was performed on infants who met the screening criteria, and retinopathy of prematurity was diagnosed according to the International Classification of Retinopathy of Prematurity. Maternal, obstetric, neonatal, and medical data were retrieved. Logistic regression analysis was used to identify the risk factors associated with retinopathy of prematurity.
RESULTS
A total of 403 premature infants were screened. The mean ± SD birth weight and gestational ages were 1,538 ± 543 grams and 31 ± 3 weeks, respectively. The incidence of any retinopathy of prematurity and stages 2 and 3 were 13.6%, 3.5%, and 10.1%, respectively. Multiple logistic regression analysis demonstrated that gestational age (adjusted odds ratio = 1.98, 95% CI:1.15-3.39), low birth weight (adjusted odds ratio = 0.99, 95% CI: 0.99-1.00), and phototherapy (adjusted odds ratio = 0.41, 95% CI: 0.17-1.00) were significant factors associated with the development of retinopathy of prematurity, after controlling for other confounding factors.
CONCLUSIONS
The incidence of total retinopathy of prematurity cases in this population was 13.6%. Overall, retinopathy of prematurity cases classified as stage 2 equated to 3.5% and stage 3 to 4.1%. Our data suggest that factors associated with retinopathy of prematurity consist of birth weight, gestational age, and phototherapy.
背景
本研究旨在调查诗里蒙库贴皇家医院早产儿视网膜病变的发病率及相关危险因素。
方法
对2011年1月至2021年12月期间接受早产儿视网膜病变筛查的早产儿病历进行回顾性分析。对符合筛查标准的婴儿进行筛查检查，并根据国际早产儿视网膜病变分类法诊断早产儿视网膜病变。收集产妇、产科、新生儿及医疗数据。采用逻辑回归分析确定与早产儿视网膜病变相关的危险因素。
结果
共筛查403例早产儿。平均出生体重±标准差和胎龄分别为1538±543克和31±3周。任何程度的早产儿视网膜病变以及2期和3期的发病率分别为13.6%、3.5%和10.1%。多因素逻辑回归分析显示，在控制其他混杂因素后，胎龄（调整优势比=1.98，95%可信区间：1.15-3.39）、低出生体重（调整优势比=0.99，95%可信区间：0.99-1.00）和光疗（调整优势比=0.41，95%可信区间：0.17-1.00）是与早产儿视网膜病变发生相关的显著因素。
结论
该人群中早产儿视网膜病变的总发病率为13.6%。总体而言，分类为2期的早产儿视网膜病变病例占3.5%，3期占4.1%。我们的数据表明，与早产儿视网膜病变相关的因素包括出生体重、胎龄和光疗。
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