Department of Cardiology, the Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, 213000, People's Republic of China.
Department of Cardiology, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu, 214023, People's Republic of China.
Clin Interv Aging. 2024 Mar 18;19:503-515. doi: 10.2147/CIA.S455588. eCollection 2024.
This study aimed to explore the association of preoperative neutrophil percentage (NEUT%) with the risk of acute kidney injury (AKI) in patients with acute myocardial infarction (AMI) having undergone coronary interventional therapy.
A single-center, retrospective and observational study was conducted. From December 2012 to June 2021, patients with AMI were enrolled and divided into AKI group and non-AKI group. The NEUT% in the two groups was compared. The association between NEUT% with the risk of post-AMI AKI was analyzed by univariate and multivariable logistic regression. Kaplan-Meier survival curve was drawn to evaluate the prognostic ability of NEUT% for short-term all-cause death following AMI.
A total of 3001 consecutive patients were enrolled with an average age of 64.38 years. AKI occurred in 327 (10.9%) patients. The NEUT% was higher in the AKI group than in the non-AKI group ([76.65±11.43]% versus [73.22±11.83]%, <0.001). NEUT% was also identified as an independent risk factor for AKI in AMI patients after adjustment (OR=1.021, 95% CI: 1.010-1.033, < 0.001). Compared with those at the lowest quartile of NEUT%, the patients at quartiles 2-4 had a higher risk of AKI ( for trend = 0.003). The odds of AKI increased by 29.0% as NEUT% increased by 1 standard deviation (OR=1.290, 95% CI: 1.087-1.531, = 0.004). After a median of 35 days follow-up, 93 patients died. Patients with a higher NEUT% presented a higher risk of all-cause death after AMI (Log rank: χ =24.753, <0.001).
In AMI patients, the peripheral blood NEUT% was positively associated with the odds of AKI and short-term all-cause mortality. NEUT% may provide physicians with more information about disease development and prognosis.
本研究旨在探讨行冠状动脉介入治疗的急性心肌梗死（AMI）患者术前中性粒细胞百分比（NEUT%）与急性肾损伤（AKI）风险的关系。
采用单中心、回顾性、观察性研究方法。2012 年 12 月至 2021 年 6 月，连续纳入 AMI 患者，分为 AKI 组和非 AKI 组。比较两组的 NEUT%。采用单因素和多因素 logistic 回归分析 NEUT%与 AMI 后 AKI 风险的关系。绘制 Kaplan-Meier 生存曲线评估 NEUT%对 AMI 后短期全因死亡的预后能力。
共纳入 3001 例连续患者，平均年龄 64.38 岁。327 例（10.9%）患者发生 AKI。AKI 组的 NEUT%高于非 AKI 组[（76.65±11.43）%比（73.22±11.83）%，<0.001]。在校正后，NEUT%也是 AMI 患者 AKI 的独立危险因素（OR=1.021，95%CI：1.010-1.033，<0.001）。与 NEUT%最低四分位相比，四分位 2-4 患者 AKI 风险更高（趋势检验=0.003）。随着 NEUT%增加 1 个标准差，AKI 的可能性增加 29.0%（OR=1.290，95%CI：1.087-1.531，=0.004）。中位随访 35 天后，93 例患者死亡。NEUT%较高的患者 AMI 后全因死亡风险更高（Log rank：χ=24.753，<0.001）。
在 AMI 患者中，外周血 NEUT%与 AKI 和短期全因死亡率的几率呈正相关。NEUT%可为医生提供更多关于疾病进展和预后的信息。
