Division of Population Health, Health Services Research and Primary Care, University of Manchester, Manchester, UK.
Division of Dentistry, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Community Dent Oral Epidemiol. 2024 Aug;52(4):601-612. doi: 10.1111/cdoe.12958. Epub 2024 Mar 25.
The addition of fluoride to community drinking water supplies has been a long-standing public health intervention to improve dental health. However, the evidence of cost-effectiveness in the UK currently lacks a contemporary focus, being limited to a period with higher incidence of caries. A water fluoridation scheme in West Cumbria, United Kingdom, provided a unique opportunity to study the contemporary impact of water fluoridation. This study evaluates the cost-effectiveness of water fluoridation over a 5-6 years follow-up period in two distinct cohorts: children exposed to water fluoridation in utero and those exposed from the age of 5.
Cost-effectiveness was summarized employing incremental cost-effectiveness ratios (ICER, cost per quality adjusted life year (QALY) gained). Costs included those from the National Health Service (NHS) and local authority perspective, encompassing capital and running costs of water fluoridation, as well as NHS dental activity. The measure of health benefit was the QALY, with utility determined using the Child Health Utility 9-Dimension questionnaire. To account for uncertainty, estimates of net cost and outcomes were bootstrapped (10 000 bootstraps) to generate cost-effectiveness acceptability curves and sensitivity analysis performed with alternative specifications.
There were 306 participants in the birth cohort (189 and 117 in the non-fluoridated and fluoridated groups, respectively) and 271 in the older school cohort (159 and 112, respectively). In both cohorts, there was evidence of small gains in QALYs for the fluoridated group compared to the non-fluoridated group and reductions in NHS dental service cost that exceeded the cost of fluoridation. For both cohorts and across all sensitivity analyses, there were high probabilities (>62%) of water fluoridation being cost-effective with a willingness to pay threshold of £20 000 per QALY.
This analysis provides current economic evidence that water fluoridation is likely to be cost-effective. The findings contribute valuable contemporary evidence in support of the economic viability of water fluoridation scheme.
在社区饮用水中添加氟化物是改善口腔健康的长期公共卫生干预措施。然而,英国目前关于成本效益的证据缺乏当代重点,仅限于龋齿发病率较高的时期。英国西坎布里亚的一项水氟化计划提供了一个独特的机会来研究水氟化的当代影响。本研究评估了在两个不同队列中进行为期 5-6 年随访的水氟化的成本效益:在子宫内暴露于水氟化的儿童和从 5 岁开始暴露于水氟化的儿童。
采用增量成本效益比(ICER,每获得一个质量调整生命年的成本)总结成本效益。成本包括来自国民保健系统(NHS)和地方当局的观点,包括水氟化的资本和运行成本,以及 NHS 牙科活动。健康效益的衡量标准是 QALY,使用儿童健康效用 9 维度问卷确定效用。为了考虑不确定性,对净成本和结果进行了自举估计(10000 次自举),以生成成本效益可接受性曲线,并使用替代规格进行敏感性分析。
出生队列中有 306 名参与者(非氟化组 189 名,氟化组 117 名),年龄较大的学校队列中有 271 名参与者(非氟化组 159 名,氟化组 112 名)。在两个队列中,与非氟化组相比,氟化组的 QALY 均有小幅度增加,并且 NHS 牙科服务成本的减少超过了氟化成本。对于两个队列和所有敏感性分析,水氟化具有成本效益的可能性很高(>62%),愿意支付的阈值为每 QALY20000 英镑。
本分析提供了当前的经济证据,表明水氟化很可能具有成本效益。这些发现提供了有价值的当代证据,支持水氟化计划的经济可行性。