-稠合环戊烯酮-吡咯烷支架的合成——一锅法中的连续氮杂-Piancatelli反应和Conia-ene型反应
Synthesis of -fused cyclopentenone-pyrrolidine scaffolds sequential aza-Piancatelli and Conia-ene type reactions in one pot.
作者信息
Solanke Pooja R, Kumar Prakash, Mainkar Prathama S, Nayani Kiranmai, Chandrasekhar Srivari
机构信息
Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
出版信息
Chem Commun (Camb). 2024 Apr 11;60(31):4234-4237. doi: 10.1039/d4cc00104d.
A novel one-pot protocol that enables sequential execution of an aza-Piancatelli rearrangement and a Conia-ene type reaction has been developed under Lewis acid catalysis. Here, a combination of B(CF) and Cu(OTf), triethylamine, and triphenylphosphine yielded a wide range of -fused cyclopentenone-pyrrolidine scaffolds in one pot with good yields and diastereoselectivity.
在路易斯酸催化下，已开发出一种新颖的一锅法协议，该协议能够依次进行氮杂 - 皮安卡特利重排和科尼亚 - 烯型反应。在此，三（三氟甲磺酰）硼和三氟甲磺酸铜、三乙胺以及三苯基膦的组合，能在一锅反应中以良好的产率和非对映选择性得到多种稠合环戊烯酮 - 吡咯烷骨架。
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