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二甲双胍在青光眼治疗中的应用。

Metformin in Glaucoma Treatment.

机构信息

Department of Pathophysiology, Medical Faculty, University of Prishtina, Prishtinë, Kosovo.

Department of Ophthalmology, University Clinical Centre of Kosova, Prishtinë, Kosovo.

出版信息

J Glaucoma. 2024 Jun 1;33(6):387-393. doi: 10.1097/IJG.0000000000002387. Epub 2024 Mar 28.

Abstract

PRCIS

Rigorous trials are essential to develop comprehensive treatment strategies that fully exploit the therapeutic potential of metformin in the treatment of glaucoma.

OBJECTIVE

The objective of this study was to evaluate the potentially beneficial effect of metformin on glaucoma risk factors and to investigate the underlying mechanisms. The aim is to contribute to the development of new treatment strategies for glaucoma.

METHODS

We searched for studies that assessed the effects of metformin on glaucoma risk factors and the associated underlying mechanisms. Our search included electronic databases such as PUBMED, EMBASE, and clinicaltrials.gov.

RESULTS

Unfortunately, we did not find any clinical trials that specifically investigated the impact of metformin on glaucoma. However, data from experimental studies demonstrated the capability of metformin to modulate various pathways that could contribute to neuroprotection in glaucoma.

CONCLUSION

In order to develop comprehensive treatment strategies that fully exploit the therapeutic potential of metformin in the treatment of glaucoma, rigorous trials are essential. These studies are necessary to demonstrate both the safety and efficacy of metformin in the context of glaucoma treatment.

摘要

PRCIS

严格的试验对于制定全面的治疗策略至关重要,这些策略将充分挖掘二甲双胍在治疗青光眼方面的治疗潜力。

目的

本研究旨在评估二甲双胍对青光眼危险因素的潜在有益作用,并探讨其潜在机制。目的是为青光眼的新治疗策略的发展做出贡献。

方法

我们搜索了评估二甲双胍对青光眼危险因素影响及其相关潜在机制的研究。我们的搜索包括 PUBMED、EMBASE 和 clinicaltrials.gov 等电子数据库。

结果

不幸的是,我们没有发现任何专门研究二甲双胍对青光眼影响的临床试验。然而,来自实验研究的数据表明,二甲双胍能够调节多种可能有助于青光眼神经保护的途径。

结论

为了制定全面的治疗策略,充分挖掘二甲双胍在治疗青光眼方面的治疗潜力,严格的试验是必不可少的。这些研究对于证明二甲双胍在青光眼治疗中的安全性和疗效是必要的。

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