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原发性皮肤黑色素瘤——2024年的管理

Primary Cutaneous Melanoma-Management in 2024.

作者信息

Dixon Anthony Joseph, Sladden Michael, Zouboulis Christos C, Popescu Catalin M, Nirenberg Alexander, Steinman Howard K, Longo Caterina, Dixon Zoe Lee, Thomas Joseph Meirion

机构信息

Department of Research, Australasian College of Cutaneous Oncology, Docklands, VIC 3008, Australia.

Research, American Osteopathic College of Dermatology, Kirksville, MO 63501, USA.

出版信息

J Clin Med. 2024 Mar 11;13(6):1607. doi: 10.3390/jcm13061607.

Abstract

: Maximizing survival for patients with primary cutaneous melanomas (melanomas) depends on an early diagnosis and appropriate management. Several new drugs have been shown to improve survival in high-risk melanoma patients. Despite well-documented guidelines, many patients do not receive optimal management, particularly when considering patient age. : to provide an update on melanoma management from the time of the decision to biopsy a suspicious skin lesion. : We reviewed melanoma-management research published between 2018 and 2023 and identified where such findings impact and update the management of confirmed melanomas. Pubmed, Google Scholar, Ovid and Cochrane Library were used as search tools. : We identified 81 publications since 2017 that have changed melanoma management; 11 in 2018, 12 in 2019, 10 in 2020, 12 in 2021, 17 in 2022 and 18 in 2023. : Delayed or inaccurate diagnosis is more likely to occur when a partial shave or punch biopsy is used to obtain the histopathology. Wherever feasible, a local excision with a narrow margin should be the biopsy method of choice for a suspected melanoma. The Breslow thickness of the melanoma remains the single most important predictor of outcome, followed by patient age and then ulceration. The BAUSSS biomarker, (Breslow thickness, Age, Ulceration, Subtype, Sex and Site) provides a more accurate method of determining mortality risk than older currently employed approaches, including sentinel lymph node biopsy. Patients with metastatic melanomas and/or nodal disease should be considered for adjuvant drug therapy (ADT). Further, high-risk melanoma patients are increasingly considered for ADT, even without disease spread. Invasive melanomas less than 1 mm thick are usually managed with a radial excision margin of 10 mms of normal skin. If the thickness is 1 to 2 mm, select a radial margin of 10 to 20 mm. When the Breslow thickness is over 2 mm, a 20 mm clinical margin is usually undertaken. In situ melanomas are usually managed with a 5 to 10 mm margin or Mohs margin control surgery. Such wide excisions around a given melanoma is the only surgery that can be regarded as therapeutic and required. Patients who have had one melanoma are at increased risk of another melanoma. Ideal ongoing management includes regular lifelong skin checks. Total body photography should be considered if the patient has many naevi, especially when atypical/dysplastic naevi are identified. Targeted approaches to improve occupational or lifestyle exposure to ultraviolet light are important. Management also needs to include the consideration of vitamin D supplementary therapy.

摘要

原发性皮肤黑色素瘤(黑色素瘤)患者的生存最大化取决于早期诊断和适当管理。已有多种新药被证明可提高高危黑色素瘤患者的生存率。尽管有详尽的指南,但许多患者并未得到最佳管理,尤其是在考虑患者年龄时。:提供从决定对可疑皮肤病变进行活检之时起黑色素瘤管理的最新情况。:我们回顾了2018年至2023年期间发表的黑色素瘤管理研究,并确定这些研究结果对确诊黑色素瘤管理的影响及更新之处。使用PubMed、谷歌学术、Ovid和考克兰图书馆作为检索工具。:我们确定自2017年以来有81篇出版物改变了黑色素瘤管理;2018年11篇,2019年12篇,2020年10篇,2021年12篇,2022年17篇,2023年18篇。:当采用部分切除或钻孔活检获取组织病理学检查时,更有可能出现诊断延迟或不准确的情况。只要可行,对于疑似黑色素瘤,局部切除且切缘窄应作为活检的首选方法。黑色素瘤的 Breslow厚度仍然是结果的最重要单一预测因素,其次是患者年龄,然后是溃疡情况。BAUSSS生物标志物(Breslow厚度、年龄、溃疡、亚型、性别和部位)比目前使用的包括前哨淋巴结活检在内的旧方法提供了一种更准确的确定死亡风险的方法。有转移性黑色素瘤和/或淋巴结疾病的患者应考虑辅助药物治疗(ADT)。此外,即使没有疾病扩散,高危黑色素瘤患者也越来越多地被考虑进行ADT。厚度小于1毫米的侵袭性黑色素瘤通常采用10毫米正常皮肤的径向切除边缘进行处理。如果厚度为1至2毫米,则选择10至20毫米的径向边缘。当Breslow厚度超过2毫米时,通常采用20毫米的临床边缘。原位黑色素瘤通常采用5至10毫米边缘或莫氏边缘控制手术进行处理。围绕特定黑色素瘤进行如此广泛的切除是唯一可被视为治疗性且必需的手术。患过一次黑色素瘤的患者患另一次黑色素瘤的风险增加。理想的持续管理包括终身定期皮肤检查。如果患者有许多痣,尤其是发现非典型/发育异常痣时,应考虑进行全身摄影。改善职业或生活方式中紫外线暴露的针对性方法很重要。管理还需要包括对维生素D补充疗法的考虑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b05/10971470/4943fde5baa8/jcm-13-01607-g001.jpg

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