Satorres-Pérez Elena, Martínez-Varea Alicia, Novillo-Del Álamo Blanca, Morales-Roselló José, Diago-Almela Vicente
Department of Gynecology and Obstetrics, La Fe University and Polytechnic Hospital, 46026 Valencia, Spain.
Department of Pediatrics, Obstetrics and Gynecology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain.
J Clin Med. 2024 Mar 20;13(6):1784. doi: 10.3390/jcm13061784.
This study aims to assess the utility of the sFlt-1/PlGF ratio throughout pregnancy in predicting placental dysfunction and neonatal outcomes in twin pregnancies. Prospective study at a tertiary hospital. All pregnant women with a twin pregnancy who signed the informed consent were included. The sFlt-1/PlGF ratio was measured at 12, 24, and 32 weeks' gestation. Seventy patients were included, and 30% developed placental dysfunction. Differences were found in the mean sFlt-1/PlGF ratios at week 32 (13.6 vs. 31.8, = 0.007). Optimal cutoffs at 12, 24, and 32 weeks to identify patients who develop placental dysfunction were 32.5, 8.5, and 30.5, respectively, with ORs of 4.25 (1.13-20.69 95% IC; = 0.044), 13.5 (3.07-67.90 95% IC; = 0.001), 14.29 (3.59-66.84 95% IC; < 0.001). The sFlt-1/PlGF ratio at 32 weeks was associated with gestational age at birth. The sFlt-1/PlGF ratio in weeks 24 and 32 had a statistically significant negative correlation with the birth weight percentile in both twins. The potential of the sFlt-1/PlGF ratio as a predictive tool for placental dysfunction in twin pregnancies is underscored.
本研究旨在评估整个孕期sFlt-1/PlGF比值在预测双胎妊娠胎盘功能障碍及新生儿结局中的作用。在一家三级医院进行的前瞻性研究。纳入所有签署知情同意书的双胎妊娠孕妇。在妊娠12、24和32周时测量sFlt-1/PlGF比值。共纳入70例患者，其中30%发生胎盘功能障碍。在32周时，两组的平均sFlt-1/PlGF比值存在差异（13.6对31.8，P = 0.007）。在12、24和32周时，用于识别发生胎盘功能障碍患者的最佳截断值分别为32.5、8.5和30.5，其比值比分别为4.25（95%置信区间1.13 - 20.69；P = 0.044）、13.5（95%置信区间3.07 - 67.90；P = 0.001）、14.29（95%置信区间3.59 - 66.84；P < 0.001）。32周时的sFlt-1/PlGF比值与出生孕周相关。24周和32周时的sFlt-1/PlGF比值与双胎的出生体重百分位数均呈显著负相关。强调了sFlt-1/PlGF比值作为双胎妊娠胎盘功能障碍预测工具的潜力。
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