三唑并噻二嗪的合成方法及药理活性：综述。

Department of Physical Sciences, Chemistry Division, College of Science, Jazan University, P.O. Box 114, Jazan 45142, Saudi Arabia.

Chemical Industry Research Institute, National Research Centre, Dokki, Giza P.O. Box 12622, Egypt.

Molecules. 2024 Mar 16;29(6):1326. doi: 10.3390/molecules29061326.

This review article examines the synthetic pathways for triazolothiadiazine derivatives, such as triazolo[3,4-]thiadiazines, triazolo[5,1-]thiadiazines, and triazolo[4,3-]thiadiazines, originating from triazole derivatives, thiadiazine derivatives, or thiocarbohydrazide. The triazolothiadiazine derivatives exhibit several biological actions, including antibacterial, anticancer, antiviral, antiproliferative, analgesic, anti-inflammatory, and antioxidant properties. The review article aims to assist researchers in creating new biologically active compounds for designing target-oriented triazolothiadiazine-based medicines to treat multifunctional disorders.

这篇综述文章探讨了三唑并噻二嗪衍生物的合成途径，如三唑并[3,4-]噻二嗪、三唑并[5,1-]噻二嗪和三唑并[4,3-]噻二嗪，它们来源于三唑衍生物、噻二嗪衍生物或硫代碳酰肼。三唑并噻二嗪衍生物具有多种生物活性，包括抗菌、抗癌、抗病毒、抗增殖、镇痛、抗炎和抗氧化特性。综述文章旨在帮助研究人员创造新的具有生物活性的化合物，以设计基于三唑并噻二嗪的靶向药物，用于治疗多功能障碍。