神经导向因子及其受体在癌症中的研究进展。
Research progress of the netrins and their receptors in cancer.
机构信息
Department of Digestive Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China.
Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China.
出版信息
J Cell Mol Med. 2024 Apr;28(8):e18241. doi: 10.1111/jcmm.18241.
Netrins, a family of secreted and membrane-associated proteins, can regulate axonal guidance, morphogenesis, angiogenesis, cell migration, cell survival, and tumorigenesis. Four secreted netrins (netrin 1, 3, 4 and 5) and two glycosylphosphatidylinositols-anchored membrane proteins, netrin-G1 and G2, have been identified in mammals. Netrins and their receptors can serve as a biomarker and molecular therapeutic target for pathological differentiation, diagnosis and prognosis of malignant cancers. We review here the potential roles of the netrins family and their receptors in cancer.
神经导向因子是一组分泌型和膜结合型蛋白，能够调节轴突导向、形态发生、血管生成、细胞迁移、细胞存活和肿瘤发生。在哺乳动物中已鉴定出 4 种分泌型神经导向因子（神经导向因子 1、3、4 和 5）和 2 种糖基磷脂酰肌醇锚定膜蛋白，即神经导向因子 G1 和 G2。神经导向因子及其受体可作为恶性肿瘤病理分化、诊断和预后的生物标志物和分子治疗靶点。本文综述了神经导向因子家族及其受体在癌症中的潜在作用。
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