革命性的达托霉素剂量调整：一种适用于实际应用的单次 7-11 小时样本。
Revolutionizing Daptomycin Dosing: A Single 7-11-Hour Sample for Pragmatic Application.
机构信息
Clinical Pharmacology and Toxicology Institute, University Hospital Friuli Centrale ASUFC, Udine, Italy.
Department of Medicine (DMED), University of Udine (UNIUD), Udine, Italy.
出版信息
Clin Infect Dis. 2024 Sep 26;79(3):596-599. doi: 10.1093/cid/ciae178.
PMID:38552199
Abstract
Precision daptomycin dosing faces clinical implementation barriers despite known exposure-safety concerns with the use of twice the regulatory-approved doses. We propose achieving a single 7-11-hour post-dose plasma target concentration of 30 mg/L to 43 mg/L to be a practical starting point to facilitate precision daptomycin dosing.
摘要
尽管已知使用两倍监管批准剂量存在暴露安全性问题，但精准达托霉素给药仍面临临床实施障碍。我们建议将单次给药后 7-11 小时的血浆靶浓度达到 30-43mg/L 作为精准达托霉素给药的一个实用起点。
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