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探索氯胺酮作为产后抑郁症麻醉剂和抗抑郁药的疗效:一项案例研究分析。

Exploring the Efficacy of Ketamine as an Anesthetic and Antidepressant in Postpartum Depression: A Case Study Analysis.

作者信息

Benjamin Clara, Atalay Rediet Tefera, Kolawole Oluwapelumi, Ramallo Miguel, McAllister Valerie, Akinyemi Oluwasegun A, Siraga Mahlet, Michael Miriam B

机构信息

Internal Medicine, Howard University College of Medicine, Washington, D.C., USA.

Internal Medicine, Howard University Hospital, Washington, D.C., USA.

出版信息

Cureus. 2024 Feb 29;16(2):e55208. doi: 10.7759/cureus.55208. eCollection 2024 Feb.

DOI:10.7759/cureus.55208
PMID:38558697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10981165/
Abstract

Postpartum depression is a common mental health disorder that affects women within six months after giving birth. It is characterized by sadness, anxiety, and extreme fatigue, which can significantly impact a woman's daily functioning and ability to care for her newborn. While traditional treatments for postpartum depression include therapy and medication, recent studies have shown promising results using ketamine. We present a case of a woman with a history of depression who delivered four children by cesarean section with debilitating postpartum depression in two births and no symptoms of depression in the births where she received ketamine during delivery.

摘要

产后抑郁症是一种常见的心理健康障碍,会影响产后六个月内的女性。其特征为悲伤、焦虑和极度疲劳,这会严重影响女性的日常功能以及照顾新生儿的能力。虽然产后抑郁症的传统治疗方法包括心理治疗和药物治疗,但最近的研究表明,使用氯胺酮取得了令人鼓舞的结果。我们报告了一例有抑郁症病史的女性病例,她剖宫产分娩了四个孩子,其中两次分娩后患有严重的产后抑郁症,而在分娩期间接受氯胺酮治疗的两次分娩中没有抑郁症症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd4/10981165/af06cd02f22a/cureus-0016-00000055208-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd4/10981165/af06cd02f22a/cureus-0016-00000055208-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd4/10981165/af06cd02f22a/cureus-0016-00000055208-i01.jpg

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Exploring the Efficacy of Ketamine as an Anesthetic and Antidepressant in Postpartum Depression: A Case Study Analysis.探索氯胺酮作为产后抑郁症麻醉剂和抗抑郁药的疗效:一项案例研究分析。
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本文引用的文献

1
Prevalence and Risk Factors of Postpartum Depression in Women: A Systematic Review and Meta-analysis.产后抑郁症在女性中的流行情况及危险因素:系统评价和荟萃分析。
J Clin Nurs. 2022 Oct;31(19-20):2665-2677. doi: 10.1111/jocn.16121. Epub 2021 Nov 8.
2
Homicide During Pregnancy and the Postpartum Period in the United States, 2018-2019.美国 2018-2019 年妊娠期和产后期间的杀人事件。
Obstet Gynecol. 2021 Nov 1;138(5):762-769. doi: 10.1097/AOG.0000000000004567.
3
Intraoperative ketamine for reduction in postpartum depressive symptoms after cesarean delivery: A double-blind, randomized clinical trial.
剖宫产术后术中氯胺酮减轻产后抑郁症状的效果:一项双盲、随机临床试验。
Brain Behav. 2020 Sep;10(9):e01715. doi: 10.1002/brb3.1715. Epub 2020 Aug 18.
4
A Comprehensive Analysis of Post-partum Depression Risk Factors: The Role of Socio-Demographic, Individual, Relational, and Delivery Characteristics.产后抑郁风险因素的综合分析:社会人口学、个体、人际关系及分娩特征的作用
Front Public Health. 2019 Oct 24;7:295. doi: 10.3389/fpubh.2019.00295. eCollection 2019.
5
Prophylactic use of ketamine reduces postpartum depression in Chinese women undergoing cesarean section.预防性使用氯胺酮可降低中国剖宫产产妇产后抑郁的发生率。
Psychiatry Res. 2019 Sep;279:252-258. doi: 10.1016/j.psychres.2019.03.026. Epub 2019 Mar 16.
6
Consequences of maternal postpartum depression: A systematic review of maternal and infant outcomes.产后抑郁症的后果:对母婴结局的系统评价
Womens Health (Lond). 2019 Jan-Dec;15:1745506519844044. doi: 10.1177/1745506519844044.
7
Effects of Perinatal Exposure to Ketamine on the Developing Brain.围产期接触氯胺酮对发育中大脑的影响。
Front Neurosci. 2019 Feb 22;13:138. doi: 10.3389/fnins.2019.00138. eCollection 2019.
8
The role of reproductive hormones in postpartum depression.生殖激素在产后抑郁症中的作用。
CNS Spectr. 2015 Feb;20(1):48-59. doi: 10.1017/S1092852914000480. Epub 2014 Sep 29.
9
Epidural labor analgesia is associated with a decreased risk of postpartum depression: a prospective cohort study.硬膜外分娩镇痛与产后抑郁症风险降低相关:一项前瞻性队列研究。
Anesth Analg. 2014 Aug;119(2):383-392. doi: 10.1213/ANE.0000000000000107.
10
Postpartum depression: current status and future directions.产后抑郁症:现状与未来方向。
Annu Rev Clin Psychol. 2013;9:379-407. doi: 10.1146/annurev-clinpsy-050212-185612. Epub 2013 Feb 1.